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  Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

Hanekom, W. A., Dockrell, H. M., Ottenhoff, T. H. M., Doherty, T. M., Fletcher, H., McShane, H., et al. (2008). Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. PLoS Medicine, 5(7): 145, pp. 1033-1036.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C1AE-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-C1AF-5
Genre: Journal Article
Alternative Title : PLos Med.

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PLoS_Med_2008_5_e145_1033.pdf (Publisher version), 2MB
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Copyright: © 2008 Hanekom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Creators:
Hanekom, Willem A., Author
Dockrell, Hazel M., Author
Ottenhoff, Tom H. M., Author
Doherty, T. Mark, Author
Fletcher, Helen, Author
McShane, Helen, Author
Weichold, Frank F., Author
Hoft, Dan F., Author
Parida, Shreemanta K.1, Author           
Fruth, Uli J., Author
Affiliations:
1Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664146              

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 Abstract: Summary Points * Many new and diverse tuberculosis vaccines are currently under development. * The ability to compare clinical immunogenicity between different candidates would be an important asset. * The World Health Organization (WHO) Initiative for Vaccine Research sponsored three meetings of experts to discuss assay harmonization for new tuberculosis vaccine trials. * We describe advantages and disadvantages of multiple T cell assay approaches and make specific recommendations for phase I/IIa trials. These include introducing a single and simple harmonised assay for all trials.

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Language(s): eng - English
 Dates: 2008-07
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 400828
ISI: 000257970500008
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Title: PLoS Medicine
  Alternative Title : PLos Med.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 5 (7) Sequence Number: 145 Start / End Page: 1033 - 1036 Identifier: ISSN: 1549-1277