English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Who Ate Whom? Adaptive Helicobacter Genomic Changes That Accompanied a Host Jump from Early Humans to Large Felines

Eppinger, M., Baar, C., Linz, B., Raddatz, G., Lanz, C., Keller, H., et al. (2006). Who Ate Whom? Adaptive Helicobacter Genomic Changes That Accompanied a Host Jump from Early Humans to Large Felines. PLoS Genetics, 2(7): e120, pp. 1097-1110. doi:10.1371/journal.pgen.0020120.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : PLoS Genet

Files

show Files
hide Files
:
PLoS_Genet_2(7)_e120.pdf (Publisher version), 4MB
Name:
PLoS_Genet_2(7)_e120.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2006 Eppinger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License:
-

Locators

show

Creators

show
hide
 Creators:
Eppinger, Mark, Author
Baar, Claudia, Author
Linz, Bodo1, Author           
Raddatz, Günter2, Author
Lanz, Christa2, Author
Keller, Heike2, Author
Morelli, Giovanna1, Author           
Gressmann, Helga1, Author           
Achtman, Mark1, Author           
Schuster, Stephan C.2, Author
Affiliations:
1Department of Molecular Biology, Max Planck Institute for Infection Biology, Max Planck Society, ou_1664147              
2Max Planck Society, ou_persistent13              

Content

show
hide
Free keywords: -
 Abstract: Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for large felines, including cheetahs, lions, and tigers, whereas hosts more closely related to humans harbor more distantly related Helicobacter species. This observation suggests a jump between host species. But who ate whom and when did it happen? In order to resolve this question, we determined the genomic sequence of H. acinonychis strain Sheeba and compared it to genomes from H. pylori. The conserved core genes between the genomes are so similar that the host jump probably occurred within the last 200,000 (range 50,000–400,000) years. However, the Sheeba genome also possesses unique features that indicate the direction of the host jump, namely from early humans to cats. Sheeba possesses an unusually large number of highly fragmented genes, many encoding outer membrane proteins, which may have been destroyed in order to bypass deleterious responses from the feline host immune system. In addition, the few Sheeba-specific genes that were found include a cluster of genes encoding sialylation of the bacterial cell surface carbohydrates, which were imported by horizontal genetic exchange and might also help to evade host immune defenses. These results provide a genomic basis for elucidating molecular events that allow bacteria to adapt to novel animal hosts.

Details

show
hide
Language(s): eng - English
 Dates: 2006-07-28
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS Genetics
  Alternative Title : PLoS Genet
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 2 (7) Sequence Number: e120 Start / End Page: 1097 - 1110 Identifier: -