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  It takes two to tango: PROPPINs use two phosphoinositide-binding sites.

Thumm, M., Busse, R. A., Scacioc, A., Stephan, M., Janshoff, A., Kühnel, K., et al. (2013). It takes two to tango: PROPPINs use two phosphoinositide-binding sites. Autophagy, 9(1), 106-107. doi:10.4161/auto.22400.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-DDEE-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CEE9-8
Genre: Journal Article

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1693750.pdf (Publisher version), 809KB
 
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 Creators:
Thumm, M., Author
Busse, R. A.1, Author              
Scacioc, A.1, Author              
Stephan, M., Author
Janshoff, A., Author
Kühnel, K.1, Author              
Krick, R., Author
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Free keywords: autophagy, protein-lipid interactions, X-ray crystallography, S. cerevisiae
 Abstract: PROPPINs are a family of PtdIns3P and PtdIns(3,5)P2-binding proteins. The crystal structure now unravels the presence of two distinct phosphoinositide-binding sites at the circumference of the seven bladed β-propeller. Mutagenesis analysis of the binding sites shows that both are required for normal membrane association and autophagic activities. We identified a set of evolutionarily conserved basic and polar residues within both binding pockets, which are crucial for phosphoinositide binding. We expect that membrane association of PROPPINs is further stabilized by membrane insertions and interactions with other proteins

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Language(s): eng - English
 Dates: 2013-01
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.4161/auto.22400
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Title: Autophagy
Source Genre: Journal
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Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 106 - 107 Identifier: -