English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Activation of autophagy in cells with abnormal karyotype

Stingele, S., Stöhr, G., & Storchova, Z. (2013). Activation of autophagy in cells with abnormal karyotype. AUTOPHAGY, 9(2), 246-248. doi:10.4161/auto.22558.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Stingele, Silvia1, Author              
Stöhr, Gabriele2, Author              
Storchova, Zuzana1, Author              
Affiliations:
1Storchova, Zuzana / Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565171              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Content

show
hide
Free keywords: aneuploidy; trisomy; cancer; autophagy; SQSTM1-mediated selective autophagy;
 Abstract: The presence of even one extra chromosome severely impairs cellular growth. This effect of aneuploidy (a term describing chromosome numbers deviating from multiples of haploid chromosome content) has been observed in many different organisms, from yeast to humans. Accordingly, abnormal karyotypes are detected in nearly 30% of spontaneously aborted embryos. The rarely surviving infants, such as with trisomy of chromosome 21, are severely handicapped. The causes remain enigmatic, although recent studies exploiting yeast and mouse models provided first glimpses of the imbalanced inner life of aneuploid cells. Using comparative genomics, transcriptomics and proteomics we have analyzed the fate of the transcripts and proteins coded on the extra chromosomes as well as the general response to aneuploidy in human cells.

Details

show
hide
Language(s): eng - English
 Dates: 2013-02
 Publication Status: Published in print
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000314218700015
DOI: 10.4161/auto.22558
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: AUTOPHAGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA : LANDES BIOSCIENCE
Pages: - Volume / Issue: 9 (2) Sequence Number: - Start / End Page: 246 - 248 Identifier: ISSN: 1554-8627