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  Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila

Nelson, B., Freisinger, T., Ishii, K., Okado, K., Shinzawa, N., Fukumoto, S., et al. (2013). Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(3), 1120-1125. doi:10.1016/j.bbrc.2012.12.027.

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 Creators:
Nelson, Bryce1, Author
Freisinger, Tina2, Author           
Ishii, Kenichi1, Author
Okado, Kiyoshi1, Author
Shinzawa, Naoaki1, Author
Fukumoto, Shinya1, Author
Kanuka, Hirotaka1, Author
Affiliations:
1external, ou_persistent22              
2Wedlich-Söldner, Roland / Cellular Dynamics and Cell Patterning, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565174              

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Free keywords: INNATE IMMUNE-RESPONSE; POSITIVE BACTERIAL-INFECTIONS; KAPPA-B KINASE; PEPTIDOGLYCAN-RECOGNITION; ANTIBACTERIAL DEFENSE; INDUCIBLE EXPRESSION; DEFICIENCY IMD; TOLL PATHWAY; MELANOGASTER; RELISHInfection; Bacteria; Innate immunity; Drosophila; Antimicrobial peptide;
 Abstract: Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria. (C) 2012 Elsevier Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2013-01-18
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Source Genre: Journal
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Publ. Info: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA : ACADEMIC PRESS INC ELSEVIER SCIENCE
Pages: - Volume / Issue: 430 (3) Sequence Number: - Start / End Page: 1120 - 1125 Identifier: ISSN: 0006-291X