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  Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields

Labadie, C., Lee, J.-H., Rooney, W. D., Jarchow, S., Aubert-Frécon, M., Springer Jr., C. S., et al. (2014). Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields. Magnetic Resonance in Medicine, 71(1), 375-387. doi:10.1002/mrm.24670.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-E02A-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-838D-A
Genre: Journal Article

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 Creators:
Labadie, Christian1, 2, 3, Author              
Lee, Jing-Huei4, Author
Rooney, William D.5, Author
Jarchow, Silvia6, Author
Aubert-Frécon, Monique2, Author
Springer Jr., Charles S.5, Author
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Laboratoire de Spectrométrie Ionique et Moléculaire, Université Claude Bernard, Lyon, France, ou_persistent22              
3Faculty of Physics and Earth Sciences, University of Leipzig, Germany, ou_persistent22              
4Biomedical Engineering, University of Cincinnati, OH, USA, ou_persistent22              
5Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA, ou_persistent22              
6Department of Clinical Radiology, Münster University, Germany, ou_persistent22              

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Free keywords: Myelin water; Longitudinal relaxation; Inverse Laplace transform; Regularization
 Abstract: Purpose: Magnetic resonance T1-weighted images are routinely used for human brain segmentation, brain parcellation, and clinical diagnosis of demyelinating diseases. Myelin is thought to influence the longitudinal relaxation commonly described by a mono-exponential recovery, although reports of bi-exponential longitudinal relaxation have been published. The purpose of this work was to investigate if a myelin water T1 contribution could be separated in geometrically sampled Look-Locker trains of low flip angle gradient echoes. Methods: T1 relaxograms from normal human brain were computed by a spatially regularized inverse Laplace transform after estimating the apparent inversion efficiency. Results: With sufficiently long inversion-time sampling (ca. 5 × T1 of cerebrospinal fluid), the T1 relaxogram revealed a short-T1 peak (106–225 ms). The apparent fraction of this water component increased in human brain white matter from 8.3% at 3 T, to 11.3% at 4 T and 15.0% at 7 T. The T2* of the short-T1 peak at 3 T was shorter, 27.9 ± 13.0 ms, than that of the long-T1 peak, 51.3 ± 5.6 ms. Conclusion: The short-T1 fraction is interpreted as the water resident in myelin. Its detection is facilitated by longer T1 of axoplasmic water at higher magnetic field.

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Language(s): eng - English
 Dates: 2012-08-182013-01-102013-03-062014-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.24670
PMID: 23468414
Other: Epub 2013
 Degree: -

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 71 (1) Sequence Number: - Start / End Page: 375 - 387 Identifier: ISSN: 0740-3194
CoNE: /journals/resource/954925538149