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  Optimizing T1-weighted imaging of cortical myelin content at 3.0 T

Bock, N. A., Hashim, E., Janik, R., Konyer, N. B., Weiss, M., Stanisz, G. J., et al. (2013). Optimizing T1-weighted imaging of cortical myelin content at 3.0 T. NeuroImage, 65, 1-12. doi:10.1016/j.neuroimage.2012.09.051.

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 Urheber:
Bock, Nicholas A.1, Autor
Hashim, Eyesha1, Autor
Janik, Rafal2, Autor
Konyer, Norman B.3, Autor
Weiss, Marcel4, Autor           
Stanisz, Greg J.2, Autor
Turner, Robert4, Autor           
Geyer, Stefan4, Autor           
Affiliations:
1Department of Medical Physics and Radiation Sciences, McMaster University, Hamilton, ON, Canada, ou_persistent22              
2Department of Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ou_persistent22              
3Imaging Research Centre, St. Joseph's Healthcare Hamilton, ON, Canada, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Schlagwörter: Magnetic resonance imaging; Brain mapping; Cortex; Myelin; Human
 Zusammenfassung: With increases in the sensitivity and resolution of anatomical MRI for the brain, methods for mapping the organization of the cerebral cortex by imaging its myelin content have emerged. This identifies major sensory and motor regions and could be used in studies of cortical organization, particularly if patterns of myelination can be visualized over the cortical surface robustly in individual subjects. The imaging problem is difficult, however, because of the relative thinness of the cerebral cortex and the low intracortical tissue contrast. In this paper, we optimize the contrast of T1-weighted MRI to help better visualize patterns of myelination. We measure a small but statistically significant difference in T1 of 171 ± 40 ms between cortical regions with low and high myelin contents in the human cortex at 3 T, and then perform simulations to choose parameters for an inversion-recovery pulse sequence that utilizes this T1 difference to increase contrast within the cortex. We show that lengthening the delay between signal acquisition and the next inversion pulse in the sequence increases intracortical contrast more effectively than does image averaging. Using the optimized sequence, we show that major myelinated regions that are relatively thick, such as the primary motor and auditory regions, can be visualized well in individuals at 3 T using whole-cortex 3D images made at 1 mm isotropic resolution, while thinner regions, such as the primary visual cortex, can be visualized using targeted 3D images made at 0.5 mm isotropic resolution. Our findings demonstrate that patterns of myelination can be better visualized in individual subjects when the imaging is optimized to highlight intracortical contrast and can help to pave the way for the creation of matched maps of microanatomy and function in the cortex of living individual humans.

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Sprache(n): eng - English
 Datum: 2012-09-182012-10-012013-01-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2012.09.051
PMID: 23036446
Anderer: Epub 2012
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 65 Artikelnummer: - Start- / Endseite: 1 - 12 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166