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  The role of biogeography in shaping diversity of the intestinal microbiota in house mice

Linnenbrink, M., Wang, J., Hardouin, E. A., Künzel, S., Metzler, D., & Baines, J. F. (2013). The role of biogeography in shaping diversity of the intestinal microbiota in house mice. Molecular Ecology, 22(7), 1904-1916. doi:10.1111/mec.12206.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-E4BD-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-E4BF-2
Genre: Journal Article

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 Creators:
Linnenbrink, Miriam1, Author              
Wang, Jun2, Author              
Hardouin, Emilie A.1, Author              
Künzel, Sven1, Author              
Metzler, Dirk, Author
Baines, John F.2, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              
2Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: biogeography; house mouse; intestinal microbiota; Mus musculus; population structure
 Abstract: The microbial communities inhabiting the mammalian intestinal tract play an important role in diverse aspects of host biology. However, little is known regarding the forces shaping variation in these communities and their influence on host fitness. To shed light on the contributions of host genetics, transmission and geography to diversity in microbial communities between individuals, we performed a survey of intestinal microbial communities in a panel of 121 house mice derived from eight locations across Western Europe using pyrosequencing of the bacterial 16S rRNA gene. The host factors studied included population structure estimated by microsatellite loci and mitochondrial DNA, genetic distance and geography. To determine whether host tissue (mucosa)-associated communities display properties distinct from those of the lumen, both the caecal mucosa and contents were examined. We identified Bacteroides, Robinsoniella and Helicobacter as the most abundant genera in both the caecal content and mucosa-associated communities of wild house mice. Overall, we found geography to be the most significant factor explaining patterns of diversity in the intestinal microbiota, with a comparatively weaker influence of host population structure and genetic distance. Furthermore, the influence of host genetic distance was limited to the mucosa communities, consistent with this environment being more intimately coupled to the host.

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Language(s): eng - English
 Dates: 2012-12-062012-03-092012-12-112013-02-07
 Publication Status: Published online
 Pages: 13 S.
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/mec.12206
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Title: Molecular Ecology
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Science
Pages: - Volume / Issue: 22 (7) Sequence Number: - Start / End Page: 1904 - 1916 Identifier: ISSN: 0962-1083 (print)
ISSN: 1365-294X (online)
CoNE: /journals/resource/954925580119