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  Managing intracellular transport.

Chua, J. J., Jahn, R., & Klopfenstein, D. R. (2013). Managing intracellular transport. Worm, 2(1): 21564. doi:10.4161/worm.21564.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-E8C3-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CD70-F
Genre: Journal Article

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 Creators:
Chua, J. J.1, Author              
Jahn, R.2, Author              
Klopfenstein, Dieter R., Author
Affiliations:
1Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society, ou_1933287              
2Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Free keywords: Axonal transport, transport defects, neurodegeneration, autophagy, FEZ1, Kinesin, Syntaxin, Munc18, SNARE, synapse
 Abstract: Formation and normal function of neuronal synapses are intimately dependent on the delivery to and removal of biological materials from synapses by the intracellular transport machinery. Indeed, defects in intracellular transport contribute to the development and aggravation of neurodegenerative disorders. Despite its importance, regulatory mechanisms underlying this machinery remain poorly defined. We recently uncovered a phosphorylation-regulated mechanism that controls FEZ1-mediated Kinesin-1 based delivery of Stx1 into neuronal axons. Using C. elegans as a model organism to investigate transport defects, we show that FEZ1 mutations resulted in abnormal Stx1 aggregation in neuronal cell bodies and axons. This phenomenon closely resembles transport defects observed in neurodegenerative disorders. Importantly, diminished transport due to mutations of FEZ1 and Kinesin-1 were concomitant with increased accumulation of autophagosomes. Here, we discuss the significance of our findings in a broader context in relation to regulation of Kinesin-mediated transport and neurodegenerative disorders.

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Language(s): eng - English
 Dates: 2012-072013
 Publication Status: Published in print
 Pages: 4
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.4161/worm.21564
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Title: Worm
Source Genre: Journal
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Pages: - Volume / Issue: 2 (1) Sequence Number: 21564 Start / End Page: - Identifier: -