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  Ataxin-2-like is a regulator of stress granules and processing bodies

Kähler, C., Isensee, J., Nonhoff, U., Terrey, M., Hucho, T., Lehrach, H., et al. (2012). Ataxin-2-like is a regulator of stress granules and processing bodies. PLoS One, 7(11), e50134-e50134. doi:10.1371/journal.pone.0050134.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-EC72-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-EC73-C
Genre: Journal Article

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2012 Kähler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Creators:
Kähler, Christian1, Author              
Isensee, Jörg2, 3, Author              
Nonhoff, Ute4, Author              
Terrey, Markus, Author
Hucho, Tim2, 3, Author              
Lehrach, Hans4, Author              
Krobitsch, Sylvia1, Author              
Affiliations:
1Neurodegenerative Disorders (Sylvia Krobitsch), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479661              
2Signal Transduction in Mental Retardation and Pain (Tim Hucho), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479646              
3Universitätsklinik Köln, Klinik für Anästhesiologie und Operative Intensivmedizin, Experimentelle Anästhesiologie und Schmerzforschung, Cologne, Germany, ou_persistent22              
4Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ataxin-2 itself. Furthermore, we found that ataxin-2-like is a component of stress granules. Interestingly, sole ataxin-2-like overexpression led to the induction of stress granules, while a reduction of stress granules was detected in case of a low ataxin-2-like level. Finally, we observed that overexpression of ataxin-2-like as well as its reduction has an impact on the presence of microscopically visible processing bodies. Thus, our results imply a functional overlap between ataxin-2-like and ataxin-2, and further indicate a role for ataxin-2-like in the regulation of stress granules and processing bodies.

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Language(s): eng - English
 Dates: 2012-11-17
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0050134
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (11) Sequence Number: - Start / End Page: e50134 - e50134 Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850