English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genetic Variation in the Neuropeptide Y Gene Promoter Is Associated with Increased Risk of Tobacco Smoking

Mutschler, J., Abbruzzese, E., von der Goltz, C., Dinter, C., Mobascher, A., Thiele, H., et al. (2012). Genetic Variation in the Neuropeptide Y Gene Promoter Is Associated with Increased Risk of Tobacco Smoking. European Addiction Research, 18(5), 246-252. doi:10.1159/000338276.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-EC7A-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-EC7B-B
Genre: Journal Article

Files

show Files
hide Files
:
Mutschler.pdf (Publisher version), 179KB
Name:
Mutschler.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2012 S. Karger AG, Basel
License:
-

Locators

show

Creators

show
hide
 Creators:
Mutschler, J., Author
Abbruzzese, E., Author
von der Goltz, C., Author
Dinter, C., Author
Mobascher, A., Author
Thiele, H., Author
Diaz-Lacava, A., Author
Dahmen, N., Author
Gallinat, J., Author
Majic, T., Author
Petrovsky, N., Author
Kornhuber, J., Author
Thuerauf, N., Author
Grunder, G., Author
Brinkmeyer, J., Author
Wienker, T.1, 2, Author              
Wagner, M., Author
Winterer, G., Author
Kiefer, F., Author
Affiliations:
1Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479643              
2Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany, ou_persistent22              

Content

show
hide
Free keywords: Neuropeptide Y Polymorphism Nicotine Tobacco Smoking Genetics rs16147
 Abstract: Background: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. Methods: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI). Results: Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037). Conclusions: Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings.

Details

show
hide
Language(s): eng - English
 Dates: 2012-05-152012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1159/000338276
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Addiction Research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Basel : Karger
Pages: - Volume / Issue: 18 (5) Sequence Number: - Start / End Page: 246 - 252 Identifier: ISSN: 1022-6877
CoNE: /journals/resource/954925586301