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  Neurocognitive impairments in non-deprived smokers-results from a population-based multi-center study on smoking-related behavior

Wagner, M., Schulze-Rauschenbach, S., Petrovsky, N., Brinkmeyer, J., von der Goltz, C., Grunder, G., et al. (2012). Neurocognitive impairments in non-deprived smokers-results from a population-based multi-center study on smoking-related behavior. Addiction Biology, 2012, e-e. doi:10.1111/j.1369-1600.2011.00429.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-EC88-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-EC89-B
Genre: Journal Article

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© 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction
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 Creators:
Wagner, M., Author
Schulze-Rauschenbach, S., Author
Petrovsky, N., Author
Brinkmeyer, J., Author
von der Goltz, C., Author
Grunder, G., Author
Spreckelmeyer, K. N., Author
Wienker, T.1, 2, Author              
Diaz-Lacava, A., Author
Mobascher, A., Author
Dahmen, N., Author
Clepce, M., Author
Thuerauf, N., Author
Kiefer, F., Author
de Millas, J. W., Author
Gallinat, J., Author
Winterer, G., Author
Affiliations:
1Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479643              
2Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany, ou_persistent22              

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Free keywords: Attention; cognition; impulsivity; nicotine; smoking; tobacco
 Abstract: The aim of the present study was to examine neurocognitive function associated with chronic nicotine use. A total of 2163 healthy participants (1002 smokers, 1161 never-smoking controls) participated in a population-based case-control design. The main outcome measures were six cognitive domain factors derived from a neuropsychological test battery. In smokers, the battery was administered after controlled smoking of one cigarette. Analyses included age, sex and education as covariates. Results demonstrated small, but significant deficits in smokers for visual attention (P < 0.001) and cognitive impulsivity (P < 0.006), while verbal episodic memory, verbal fluency, verbal working memory, and Stroop-interference did not differ between groups. These attention/impulsivity deficits were also present in smokers with only a low amount of cigarette consumption. Lifetime nicotine use (pack-years) was not correlated with cognition in smokers. In conclusion, this study confirmed subtle and specific cognitive deficits in non-deprived smokers. The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use.

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Language(s): eng - English
 Dates: 2012-02-17
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/j.1369-1600.2011.00429.x
 Degree: -

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Title: Addiction Biology
  Other : Addict. Biol.
Source Genre: Journal
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Publ. Info: Abingdon, Oxfordshire, UK : Carfax
Pages: - Volume / Issue: 2012 Sequence Number: - Start / End Page: e - e Identifier: ISSN: 1355-6215
CoNE: /journals/resource/954925277561