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  FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin

Meyer, M., Mueller, A.-K., Yang, J., Moik, D., Ponzio, G., Ornitz, D. M., et al. (2012). FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. JOURNAL OF CELL SCIENCE, 125(23), 5690-5701. doi:10.1242/jcs.108167.

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 Creators:
Meyer, Michael1, Author
Mueller, Anna-Katharina1, Author
Yang, Jingxuan1, Author
Moik, Daniel2, Author              
Ponzio, Gilles1, Author
Ornitz, David M.1, Author
Grose, Richard1, Author
Werner, Sabine1, Author
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1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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 Abstract: Efficient wound repair is essential for the maintenance of the integrity of the skin. The repair process is controlled by a variety of growth factors and cytokines, and their abnormal expression or activity can cause healing disorders. Here, we show that wound repair is severely delayed in mice lacking fibroblast growth factor receptors (FGFR) 1 and 2 in keratinocytes. As the underlying mechanism, we identified impaired wound contraction and a delay in re-epithelialization that resulted from impaired keratinocyte migration at the wound edge. Scratch wounding and transwell assays demonstrated that FGFR1/2-deficient keratinocytes had a reduced migration velocity and impaired directional persistence owing to inefficient formation and turnover of focal adhesions. Underlying this defect, we identified a significant reduction in the expression of major focal adhesion components in the absence of FGFR signaling, resulting in a general migratory deficiency. These results identify FGFs as key regulators of keratinocyte migration in wounded skin.

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Language(s): eng - English
 Dates: 2012-12-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000315164200011
DOI: 10.1242/jcs.108167
 Degree: -

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Title: JOURNAL OF CELL SCIENCE
Source Genre: Journal
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Pages: - Volume / Issue: 125 (23) Sequence Number: - Start / End Page: 5690 - 5701 Identifier: ISSN: 0021-9533