English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Construction of a pig physical interactome using sequence homology and a comprehensive reference human interactome

Dreher, F., Kamburov, A., & Herwig, R. (2012). Construction of a pig physical interactome using sequence homology and a comprehensive reference human interactome. Evolutionary Bioinformatics, 8, 119-126. doi:10.4137/EBO.S8552.

Item is

Files

show Files
hide Files
:
Dreher.pdf (Publisher version), 2MB
Name:
Dreher.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© the author(s), publisher and licensee Libertas Academica Ltd
License:
-

Locators

show

Creators

show
hide
 Creators:
Dreher, Felix1, Author           
Kamburov, Atanas1, Author           
Herwig, Ralf1, Author           
Affiliations:
1Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479648              

Content

show
hide
Free keywords: pig protein–protein interactions, sequence homology, bioinformatics, interaction networks, genome analysis
 Abstract: The analysis of interaction networks is crucial for understanding molecular function and has an essential impact for genomewide studies. However, the interactomes of most species are largely incomplete and computational strategies that take into account sequence homology can help compensating for this lack of information using cross-species analysis. In this work we report the construction of a porcine interactome resource. We applied sequence homology matching and carried out bi-directional BLASTp searches for the currently available protein sequence collections of human and pig. Using this homology we were able to recover, on average, 71% of the proteins annotated for human pathways for the pig. Porcine protein-protein interactions were deduced from homologous proteins with known interactions in human. The result of this work is a resource comprising 204,699 predicted porcine interactions that can be used in genome analyses in order to enhance functional interpretation of data. The data can be visualized and downloaded from http://cpdb.molgen.mpg.de/pig.

Details

show
hide
Language(s): eng - English
 Dates: 2012-01-242012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.4137/EBO.S8552
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Evolutionary Bioinformatics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Auckland, New Zealand : Libertas Academica Ltd
Pages: - Volume / Issue: 8 Sequence Number: - Start / End Page: 119 - 126 Identifier: -