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  Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

Eberl, M., Klingler, S., Mangelberger, D., Loipetzberger, A., Damhofer, H., Zoidl, K., et al. (2012). Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Molecular Medicine, 4(3), 218-233. doi:10.1002/emmm.201100201.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F03F-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F040-C
Genre: Journal Article

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© 1999–2013 John Wiley & Sons, Inc.
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 Creators:
Eberl, M., Author
Klingler, S., Author
Mangelberger, D., Author
Loipetzberger, A., Author
Damhofer, H., Author
Zoidl, K., Author
Schnidar, H., Author
Hache, H.1, Author              
Bauer, H. C., Author
Solca, F., Author
Hauser-Kronberger, C., Author
Ermilov, A. N., Author
Verhaegen, M. E., Author
Bichakjian, C. K., Author
Dlugosz, A. A., Author
Nietfeld, W.2, Author              
Sibilia, M., Author
Lehrach, H.2, Author              
Wierling, C.1, Author              
Aberger, F., Author
Affiliations:
1Systems Biology (Christoph Wierling), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479656              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1433550              

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Free keywords: Animals Carcinoma, Basal Cell/genetics/*metabolism/pathology Cell Line, Tumor Fibroblast Growth Factors/genetics/metabolism *Gene Expression Regulation, Neoplastic Hedgehog Proteins/genetics/*metabolism Humans Mice Mice, Inbred C57BL Mice, Transgenic Pancreatic Neoplasms/genetics/*metabolism/pathology Phenotype Receptor, Epidermal Growth Factor/genetics/*metabolism Receptors, CXCR4/genetics/metabolism SOX9 Transcription Factor/genetics/metabolism SOXB1 Transcription Factors/genetics/metabolism Transcription Factors/genetics/metabolism Tumor Burden
 Abstract: Inhibition of Hedgehog (HH)/GLI signalling in cancer is a promising therapeutic approach. Interactions between HH/GLI and other oncogenic pathways affect the strength and tumourigenicity of HH/GLI. Cooperation of HH/GLI with epidermal growth factor receptor (EGFR) signalling promotes transformation and cancer cell proliferation in vitro. However, the in vivo relevance of HH-EGFR signal integration and the critical downstream mediators are largely undefined. In this report we show that genetic and pharmacologic inhibition of EGFR signalling reduces tumour growth in mouse models of HH/GLI driven basal cell carcinoma (BCC). We describe HH-EGFR cooperation response genes including SOX2, SOX9, JUN, CXCR4 and FGF19 that are synergistically activated by HH-EGFR signal integration and required for in vivo growth of BCC cells and tumour-initiating pancreatic cancer cells. The data validate EGFR signalling as drug target in HH/GLI driven cancers and shed light on the molecular processes controlled by HH-EGFR signal cooperation, providing new therapeutic strategies based on combined targeting of HH-EGFR signalling and selected downstream target genes.

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Language(s): eng - English
 Dates: 2012-02-012012-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/emmm.201100201
 Degree: -

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Title: EMBO Molecular Medicine
Source Genre: Journal
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Publ. Info: John Wiley & Sons, Inc.
Pages: - Volume / Issue: 4 (3) Sequence Number: - Start / End Page: 218 - 233 Identifier: -