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  Modeling of miRNA and drug action in the EGFR signaling pathway

Li, J., Pandey, V., Kessler, T., Lehrach, H., & Wierling, C. (2012). Modeling of miRNA and drug action in the EGFR signaling pathway. PLoS One, 7(1): e30140. doi:10.1371/journal.pone.0030140.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F062-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F063-D
Genre: Journal Article

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© 2012 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Creators:
Li, J., Author
Pandey, V.1, Author              
Kessler, T.1, Author              
Lehrach, H.2, Author              
Wierling, C.1, Author              
Affiliations:
1Systems Biology (Christoph Wierling), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479656              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1433550              

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Free keywords: Animals Antineoplastic Agents/*pharmacology Computer Simulation Humans Kinetics MicroRNAs/genetics/*metabolism *Models, Biological Receptor, Epidermal Growth Factor/*metabolism Signal Transduction/*drug effects
 Abstract: MicroRNAs have gained significant interest due to their widespread occurrence and diverse functions as regulatory molecules, which are essential for cell division, growth, development and apoptosis in eukaryotes. The epidermal growth factor receptor (EGFR) signaling pathway is one of the best investigated cellular signaling pathways regulating important cellular processes and its deregulation is associated with severe diseases, such as cancer. In this study, we introduce a systems biological model of the EGFR signaling pathway integrating validated miRNA-target information according to diverse studies, in order to demonstrate essential roles of miRNA within this pathway. The model consists of 1241 reactions and contains 241 miRNAs. We analyze the impact of 100 specific miRNA inhibitors (anit-miRNAs) on this pathway and propose that the embedded miRNA-network can help to identify new drug targets of the EGFR signaling pathway and thereby support the development of new therapeutic strategies against cancer.

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Language(s): eng - English
 Dates: 2012-01-11
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0030140
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (1) Sequence Number: e30140 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850