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  OCT4 and the acquisition of oocyte developmental competence during folliculogenesis

Zuccotti, M., Merico, V., Belli, M., Mulas, F., Sacchi, L., Zupan, B., et al. (2012). OCT4 and the acquisition of oocyte developmental competence during folliculogenesis. International Journal of Developmental Biology, 56(10-11-12), 853-858. doi:10.1387/ijdb.120174mz.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F0BF-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F0C0-A
Genre: Journal Article

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© 2012 UBC Press
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 Creators:
Zuccotti, M., Author
Merico, V., Author
Belli, M., Author
Mulas, F., Author
Sacchi, L., Author
Zupan, B., Author
Redi, C. A., Author
Prigione, A.1, Author              
Adjaye, J.1, 2, Author              
Bellazzi, R., Author
Garagna, S., Author
Affiliations:
1Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, Berlin, Germany, ou_1479654              
2Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heiner University, Düsseldorf, Germany, ou_persistent22              

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 Abstract: The role that the transcription factor OCT4 plays during oocyte growth is yet unknown. In this review, we summarise the data on its potential role in the acquisition of oocyte developmental competence in the mouse. These studies describe the presence in MII oocytes and 2-cell embryos of an OCT4 transcriptional network that might be part of the molecular signature of maternal origin on which the inner cell mass and the embryonic stem cell-associated pluripotency is assembled and shaped. The Oct4-gene regulatory network thus provides a connection between eggs, early preimplantation embryos and embryonic stem cells.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1387/ijdb.120174mz
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Title: International Journal of Developmental Biology
  Other : Int. J. Dev. Biol.
Source Genre: Journal
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Publ. Info: Vizcaya, Spain : University of the Basque Country Press
Pages: - Volume / Issue: 56 (10-11-12) Sequence Number: - Start / End Page: 853 - 858 Identifier: ISSN: 0214-6282
CoNE: /journals/resource/991042727990604