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  Abdominal fat distribution and its relationship to brain changes: The differential effects of age on cerebellar structure and function: A cross-sectional, exploratory study

Raschpichler, M., Straatman, K., Schroeter, M. L., Arélin, K., Schlögl, H., Fritzsch, D., et al. (2013). Abdominal fat distribution and its relationship to brain changes: The differential effects of age on cerebellar structure and function: A cross-sectional, exploratory study. BMJ Open, 3(1): e001915. doi:10.1136/bmjopen-2012-001915.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F0ED-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-AFFF-A
Genre: Journal Article

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 Creators:
Raschpichler, Matthias1, Author
Straatman, Kees2, Author
Schroeter, Matthias L.3, Author              
Arélin, Katrin3, 4, Author              
Schlögl, Haiko5, Author
Fritzsch, Dominik6, Author
Mende, Meinhard7, Author
Pampel, André8, Author              
Böttcher, Yvonne1, Author
Stumvoll, Michael5, Author
Villringer, Arno3, 4, Author              
Mueller, Karsten8, Author              
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Advanced Imaging Facilities, College of Medicine, Biological Sciences and Psychology, University of Leicester, United Kingdom, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Department of Internal Medicine, University of Leipzig, Germany, ou_persistent22              
6Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
7Clinical Trial Centre Leipzig, University of Leipzig, Germany, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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 Abstract: Objectives To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as body mass index (BMI). Moreover, we aimed to investigate whether these effects change with age. Design Cross-sectional, exploratory. Setting University Clinic, Integrative Research and Treatment Centre. Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women). Main outcome measures VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC). Results We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. This negative correlation disappeared in the elderly. Investigating functional brain architecture showed again inverse VAT–cerebellum correlations, whereas now regions involved in cognitive and emotional processing were significant. Although we detected similar results for EC using BMI, significant age interaction for both brain structure and functional architecture was only found using VAT. Conclusions Visceral adiposity is associated with cerebellar changes of both structure and function, whereas the regions involved contribute to motor, cognitive and emotional processes. Furthermore, these associations seem to be age dependent, with younger adults’ brains being adversely affected.

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Language(s): eng - English
 Dates: 2012-08-032012-11-062013-01-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1136/bmjopen-2012-001915
PMID: 23355665
PMC: PMC3563141
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Title: BMJ Open
Source Genre: Journal
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Publ. Info: London, United Kingdom : BMJ Publ. Group
Pages: - Volume / Issue: 3 (1) Sequence Number: e001915 Start / End Page: - Identifier: ISSN: 2044-6055
CoNE: https://pure.mpg.de/cone/journals/resource/2044-6055