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  An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes.

Kremer, K., Kamin, D., Rittweger, E., Wilkes, J., Flammer, H., Mahler, S., et al. (2013). An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathogens, 9(3): e1003213. doi:10.1371/journal.ppat.1003213.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F14C-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C790-C
Genre: Journal Article

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Kremer, K., Author
Kamin, D.1, Author              
Rittweger, E.1, Author              
Wilkes, J., Author
Flammer, H., Author
Mahler, S., Author
Heng, J., Author
Tonkin, C. J., Author
Langsley, G., Author
Hell, S. W.1, Author              
Carruthers, V. B., Author
Ferguson, D. J. P., Author
Meissner, M., Author
Affiliations:
1Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society, ou_578627              

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 Abstract: Eukaryotic cells evolved a highly complex endomembrane system, consisting of secretory and endocytic organelles. In the case of apicomplexan parasites unique secretory organelles have evolved that are essential for the invasion of the host cell. Surprisingly these protozoans show a paucity of trafficking factors, such as Rabs and it appears that they lost several factors involved in endocytosis. Here, we demonstrate that Rab5A and Rab5C, normally involved in endocytic uptake, actually regulate secretion in Toxoplasma gondii, since functional ablation of Rab5A or Rab5C results in aberrant transport of proteins to specialised secretory organelles called micronemes and rhoptries. Furthermore, we demonstrate that independent transport routes to micronemes exist indicating that apicomplexans have remodelled Rab5-mediated vesicular traffic into a secretory system that is essential for host cell invasion.

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Language(s): eng - English
 Dates: 2013-03-13
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.ppat.1003213
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Title: PLoS Pathogens
Source Genre: Journal
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Pages: - Volume / Issue: 9 (3) Sequence Number: e1003213 Start / End Page: - Identifier: -