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  Pilidiostigmin, a novel bioactive dimeric acylphloroglucinol derivative isolated from Pilidiostigma glabrum.

Shou, Q., Sun, H., Banbury, L., Lambley, E. H., Renshaw, D. E., Griesinger, C., et al. (2013). Pilidiostigmin, a novel bioactive dimeric acylphloroglucinol derivative isolated from Pilidiostigma glabrum. Tetrahedron Letters, 54(14), 1853-1856. doi:10.1016/j.tetlet.2013.01.107.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F5C2-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-16FB-1
Genre: Journal Article

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 Creators:
Shou, Q., Author
Sun, H.1, Author              
Banbury, L., Author
Lambley, E. H., Author
Renshaw, D. E., Author
Griesinger, C.1, Author              
Griesser, H. J., Author
Wohlgemuth, H., Author
Affiliations:
1Department of NMR based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: Pilidiostigma glabrum; Acylphloroglucinol derivative; Pilidiostigmin; Inhibition of NO synthesis
 Abstract: Pilidiostigmin, a novel dimeric acylphloroglucinol derivative, was isolated from the leaves of the Australian plant species Pilidiostigma glabrum (Myrtaceae). Pilidiostigmin exists in the plant in the form of a sodium salt, which is rare in natural products. The elucidation of the structure and relative configuration was achieved by spectroscopic measurements with special emphasis on 1D and 2D NMR techniques. Pilidiostigmin was found to display biological activity; it significantly and dose-dependently inhibited the synthesis of nitric oxide in LPS-stimulated RAW 264.7 macrophages at low micromolar concentrations. (C) 2013 Elsevier Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2013-02-042013-04-03
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tetlet.2013.01.107
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Title: Tetrahedron Letters
Source Genre: Journal
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Pages: - Volume / Issue: 54 (14) Sequence Number: - Start / End Page: 1853 - 1856 Identifier: -