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  Signal recognition initiates reorganization of the presequence translocase during protein import.

Lytofchenko, O., Melin, J., Schulz, C., Kilisch, M., Hutu, D. P., & Rehling, P. (2013). Signal recognition initiates reorganization of the presequence translocase during protein import. EMBO Journal, 32(6), 886-898. doi:10.1038/emboj.2013.23.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F735-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-08CC-8
Genre: Journal Article

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 Creators:
Lytofchenko, O., Author
Melin, J., Author
Schulz, C., Author
Kilisch, M., Author
Hutu, D. P., Author
Rehling, P.1, Author              
Affiliations:
1Max Planck Fellow Peter Rehling, ou_1298545              

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 Abstract: The mitochondrial presequence translocase interacts with presequence-containing precursors at the intermembrane space (IMS) side of the inner membrane to mediate their translocation into the matrix. Little is known as too how these matrix-targeting signals activate the translocase in order to initiate precursor transport. Therefore, we analysed how signal recognition by the presequence translocase initiates reorganization among Tim-proteins during import. Our analyses revealed that the presequence receptor Tim50 interacts with Tim21 in a signal-sensitive manner in a process that involves the IMS-domain of the Tim23 channel. The signal-driven release of Tim21 from Tim50 promotes recruitment of Pam17 and thus triggers formation of the motor-associated form of the TIM23 complex required for matrix transport.

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Language(s): eng - English
 Dates: 2013-02-122013-03-20
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/emboj.2013.23
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Title: EMBO Journal
Source Genre: Journal
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Pages: - Volume / Issue: 32 (6) Sequence Number: - Start / End Page: 886 - 898 Identifier: -