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  Reduced threshold for induction of LTP by activation of dopamine D1/D5 receptors at hippocampal CA1–subiculum synapses

Roggenhofer, E., Fidzinski, P., Shor, O., & Behr, J. (2013). Reduced threshold for induction of LTP by activation of dopamine D1/D5 receptors at hippocampal CA1–subiculum synapses. PLoS One, 8(4): e62520. doi:10.1371/journal.pone.0062520.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-F99E-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-AFF2-7
Genre: Journal Article

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Roggenhofer, Elisabeth1, 2, 3, Author              
Fidzinski, Pawel1, 3, Author
Shor, Oded1, 3, Author
Behr, Joachim1, 3, 4, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Johannes Mueller Institute of Physiology, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department of Psychiatry, Psychotherapy and Psychosomatic, Ruppiner Kliniken GmbH, Neuruppin, Germany, ou_persistent22              

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 Abstract: The phasic release of dopamine in the hippocampal formation has been shown to facilitate the encoding of novel information. There is evidence that the subiculum operates as a detector and distributor of sensory information, which incorporates the novelty and relevance of signals received from CA1. The subiculum acts as the final hippocampal relay station for outgoing information. Subicular pyramidal cells have been classified as regular- and burst-spiking neurons. The goal of the present study was to study the effect of dopamine D1/D5 receptor activation on synaptic transmission and plasticity in the subicular regular-spiking neurons of 4–6 week old Wistar rats. We demonstrate that prior activation of D1/D5 receptors reduces the threshold for the induction of long-term potentiation (LTP) in subicular regular-spiking neurons. Our results indicate that D1/D5 receptor activation facilitates a postsynaptic form of LTP in subicular regular-spiking cells that is NMDA receptor-dependent, relies on postsynaptic Ca2+ signaling, and requires the activation of protein kinase A. The enhanced propensity of subicular regular-spiking cells to express postsynaptic LTP after activation of D1/D5 receptors provides an intriguing mechanism for the encoding of hippocampal output information.

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Language(s): eng - English
 Dates: 2012-10-172013-03-212013-04-23
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0062520
PMID: 23626827
PMC: PMC3633881
Other: Print 2013
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: 10 Volume / Issue: 8 (4) Sequence Number: e62520 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850