English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Reversed timing-dependent associative plasticity in the human brain through interhemispheric interactions

Conde, V., Vollmann, H., Taubert, M., Sehm, B., Cohen, L. G., Villringer, A., et al. (2013). Reversed timing-dependent associative plasticity in the human brain through interhemispheric interactions. Journal of Neurophysiology, 109(9), 2260-2271. doi:10.1152/jn.01004.2012.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-FC21-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-ACC5-D
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Conde, Virginia1, Author              
Vollmann, Henning1, Author              
Taubert, Marco1, Author              
Sehm, Bernhard1, Author              
Cohen, Leonardo G.2, Author
Villringer, Arno1, 3, Author              
Ragert, Patrick1, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA, ou_persistent22              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

Content

show
hide
Free keywords: Paired-associative stimulation; Spike timing-dependent plasticity; Primary somatosensory cortex; Primary motor cortex; Interhemispheric inhibition
 Abstract: Spike timing-dependent plasticity (STDP) has been proposed as one of the key mechanisms underlying learning and memory. Repetitive median nerve stimulation, followed by transcranial magnetic stimulation (TMS) of the contralateral primary motor cortex (M1), defined as paired-associative stimulation (PAS), has been used as an in vivo model of STDP in humans. PAS-induced excitability changes in M1 have been repeatedly shown to be time-dependent in a STDP-like fashion, since synchronous arrival of inputs within M1 induces long-term potentiation-like effects, whereas an asynchronous arrival induces long-term depression (LTD)-like effects. Here, we show that interhemispheric inhibition of the sensorimotor network during PAS, with the peripheral stimulation over the hand ipsilateral to the motor cortex receiving TMS, results in a LTD-like effect, as opposed to the standard STDP-like effect seen for contralateral PAS. Furthermore, we could show that this reversed-associative plasticity critically depends on the timing interval between afferent and cortical stimulation. These results indicate that the outcome of associative stimulation in the human brain depends on functional network interactions (inhibition or facilitation) at a systems level and can either follow standard or reversed STDP-like mechanisms.

Details

show
hide
Language(s): eng - English
 Dates: 2012-11-192013-02-062013-02-132013-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1152/jn.01004.2012
PMID: 23407353
PMC: PMC3652216
Other: Epub 2013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Neurophysiology
  Other : J. Neurophysiol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Bethesda, MD
Pages: - Volume / Issue: 109 (9) Sequence Number: - Start / End Page: 2260 - 2271 Identifier: ISSN: 0022-3077
CoNE: https://pure.mpg.de/cone/journals/resource/954925416959