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  Patient-reported outcomes in adequately treated hypothyroidism: Insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ

Quinque, E. M., Villringer, A., Kratzsch, J., & Karger, S. (2013). Patient-reported outcomes in adequately treated hypothyroidism: Insights from the German versions of ThyDQoL, ThySRQ and ThyTSQ. Health and Quality of Life Outcomes, 11: 68. doi:10.1186/1477-7525-11-68.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-FCC7-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-ACCD-5
Genre: Journal Article

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 Creators:
Quinque, Eva Maria1, Author              
Villringer, Arno1, Author              
Kratzsch, Juergen2, Author
Karger, Stefan3, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Institute for Laboratory Medicince, University Clinic Leipzig, ou_persistent22              
3Clinic for Endocrinology, University Clinic Leipzig, ou_persistent22              

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Free keywords: Hypothyroidism; Hashimoto’s thyroiditis; Patient-reported outcome measures (PROMs); Quality of life; Linguistic validation; Patient satisfaction
 Abstract: Background Disease-specific patient-reported outcome measures (PROMs) have been developed as important research tools in the study of various diseases. For hypothyroidism there exist three validated disease-specific questionnaires in English: the Thyroid-Dependent Quality of Life Questionnaire (ThyDQoL), the Underactive Thyroid Symptom Rating Questionnaire (ThySRQ) and the Thyroid Treatment Satisfaction Questionnaire (ThyTSQ). We report psychometric properties of new German versions of the questionnaires including construct validity from two independent samples. Methods 230 envelopes with ThyDQoL, ThySRQ and ThyTSQ were given out to patients receiving levothyroxine for diagnosed hypothyroidism. Reliability and factor analyses were performed, correlations and hypothesised subgroup differences calculated to assess psychometric properties. Independently, 18 patients with treated hypothyroidism for autoimmune thyroiditis (Hashimoto’s disease) and 18 healthy control subjects were enrolled in a clinical study. Participants filled in the above questionnaires alongside well-known generic PROMs, e.g. the Beck Depression Inventory, the 12-item Well-Being Questionnaire and the Short-Form-36. Two blood samples were taken. Groups were compared and correlations between disease-specific and generic instruments analysed. Relationships between PROMs and biochemically determined thyroid hormone status were investigated. Results 102 patients returned completed questionnaires (response rate 44%). The newly translated questionnaires had satisfactory psychometric properties. Cronbach’s alpha was 0.92 for ThyDQoL, 0.81 for ThySRQ and 0.86 for ThyTSQ. For each of the questionnaires, a single factor structure explained the data best. Adequately treated patients with thyroid stimulating hormone levels in the upper normal range reported more symptoms in the ThySRQ. Those with autoimmune hypothyroidism reported being more bothered by depressive symptoms. Within the clinical sample, correlation with well-known generic instruments revealed good construct validity. In the clinical sample patients reported more symptoms in the ThySRQ, being more bothered by tiredness, higher depression and reduced well-being despite biochemically adequate treatment. Correlations between PROMs and biochemical thyroid hormone status revealed moderate though consistent associations. Conclusions Psychometric properties including construct validity of German versions of the ThyDQoL, ThySRQ and ThyTSQ are satisfactory. Feasibility and sensitivity in a clinical sample could be shown. We encourage the use of disease-specific PROMs in future studies as important additions to generic instruments in clinical research on hypothyroidism.

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Language(s): eng - English
 Dates: 2013-03-042013-04-162013-04-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/1477-7525-11-68
PMID: 23618009
PMC: PMC3735043
 Degree: -

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Title: Health and Quality of Life Outcomes
  Other : HQLO
Source Genre: Journal
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Publ. Info: London : BioMed Central
Pages: - Volume / Issue: 11 Sequence Number: 68 Start / End Page: - Identifier: ISSN: 1477-7525
CoNE: https://pure.mpg.de/cone/journals/resource/1477-7525