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  Mass sensors with mechanical traps for weighing single cells in different fluids.

Weng, Y., Delgado, F. F., Son, S., Burg, T. P., Wasserman, S. C., & Manalis, S. R. (2011). Mass sensors with mechanical traps for weighing single cells in different fluids. Lap on a Chip, 11, 4174-4180. doi:10.1039/C1LC20736A.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-FECE-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C819-0
Genre: Journal Article

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1747064.pdf (Publisher version), 361KB
 
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 Creators:
Weng, Y., Author
Delgado, F. F., Author
Son, S., Author
Burg, T. P.1, Author              
Wasserman, S. C., Author
Manalis, S. R., Author
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1Research Group of Biological Micro- and Nanotechnology, MPI for biophysical chemistry, Max Planck Society, ou_578602              

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 Abstract: We present two methods by which single cells can be mechanically trapped and continuously monitored within the suspended microchannel resonator (SMR) mass sensor. Since the fluid surrounding the trapped cell can be quickly and completely replaced on demand, our methods are well suited for measuring changes in cell size and growth in response to drugs or other chemical stimuli. We validate our methods by measuring the density of single polystyrene beads and Saccharomyces cerevisiae yeast cells with a precision of approximately 10−3 g cm−3, and by monitoring the growth of single mouse lymphoblast cells before and after drug treatment.

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Language(s): eng - English
 Dates: 2011-10-282011
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1039/C1LC20736A
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Title: Lap on a Chip
Source Genre: Journal
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Pages: - Volume / Issue: 11 Sequence Number: - Start / End Page: 4174 - 4180 Identifier: -