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  Evaluating patterns of convergent evolution and trans-species polymorphism at MHC immunogenes in two sympatric stickleback species

Lenz, T. L., Eizaguirre, C., Kalbe, M., & Milinski, M. (2013). Evaluating patterns of convergent evolution and trans-species polymorphism at MHC immunogenes in two sympatric stickleback species. Evolution, 67(8), 2400-2412. doi:10.1111/evo.12124.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-FF29-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-31A2-9
Genre: Journal Article

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 Creators:
Lenz, Tobias L.1, Author              
Eizaguirre, Christophe1, Author              
Kalbe, Martin2, Author              
Milinski, Manfred1, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              

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Free keywords: balancing selection; major histocompatibility complex (MHC); nine-spined stickleback; peptide-binding region (PBR); sequence evolution; three-spined stickleback
 Abstract: The immunologically important major histocompatibility complex (MHC) harbors some of the most polymorphic genes in vertebrates. These genes presumably evolve under parasite-mediated selection and frequently show inconsistent allelic genealogies, where some alleles are more similar between species than within species. This phenomenon is thought to arise either from convergent evolution under parallel selection or from the preservation of ancient allelic lineages beyond speciation events (trans-species polymorphism, TSP). Here, we examine natural populations of two sympatric stickleback species (Gasterosteus aculeatus and Pungitius pungitius) to investigate the contribution of these two mechanisms to the evolution of inconsistent allelic genealogies at the MHC. Overlapping parasite taxa between the two host species in three different habitats suggest contemporary parallel selection on the MHC genes. Accordingly, we detected a lack of species-specific phylogenetic clustering in the immunologically relevant antigen-binding residues of the MHC IIB genes which contrasted with the rest of the coding and noncoding sequence. However, clustering was not habitat-specific and a codon-usage analysis revealed patterns of similarity by descent. In this light, common descent via TSP, in combination with intraspecies gene conversion, rather than convergent evolution is the more strongly supported scenario for the inconsistent genealogy at the MHC.

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Language(s): eng - English
 Dates: 2012-12-182013-03-262013-04-302013-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/evo.12124
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Title: Evolution
  Other : Evolution
Source Genre: Journal
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Publ. Info: Boulder, Colo.? : Society for the Study of Evolution
Pages: - Volume / Issue: 67 (8) Sequence Number: - Start / End Page: 2400 - 2412 Identifier: ISSN: 0014-3820 (print)
ISSN: 1558-5646 (online)
CoNE: /journals/resource/991042730870254