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  Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing

Stiebens, V. A., Merino, S. E., Chain, F. J. J., & Eizaguirre, C. (2013). Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing. BMC Evolutionary Biology, 13: 95. doi: 10.1186/1471-2148-13-95.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-775D-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-775E-2
Genre: Journal Article

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 Creators:
Stiebens, Victor A., Author
Merino, Sonia E., Author
Chain, Frédéric J. J.1, Author              
Eizaguirre, Christophe1, Author              
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              

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Free keywords: major histocompatibility complex; loggerhead sea turtle; trans-species polymorphism; reptiles; intermediate diversity
 Abstract: Background In evolutionary and conservation biology, parasitism is often highlighted as a major selective pressure. To fight against parasites and pathogens, genetic diversity of the immune genes of the major histocompatibility complex (MHC) are particularly important. However, the extensive degree of polymorphism observed in these genes makes it difficult to conduct thorough population screenings. Methods We utilized a genotyping protocol that uses 454 amplicon sequencing to characterize the MHC class I in the endangered loggerhead sea turtle (Caretta caretta) and to investigate their evolution at multiple relevant levels of organization. Results MHC class I genes revealed signatures of trans-species polymorphism across several reptile species. In the studied loggerhead turtle individuals, it results in the maintenance of two ancient allelic lineages. We also found that individuals carrying an intermediate number of MHC class I alleles are larger than those with either a low or high number of alleles. Conclusions Multiple modes of evolution seem to maintain MHC diversity in the loggerhead turtles, with relatively high polymorphism for an endangered species.

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Language(s): eng - English
 Dates: 2013-01-062013-04-172013-04-30
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1186/1471-2148-13-95
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Title: BMC Evolutionary Biology
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: 11 S. Volume / Issue: 13 Sequence Number: 95 Start / End Page: - Identifier: ISSN: 1471-2148
CoNE: /journals/resource/111000136905006