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  Age dependence of hemodynamic response characteristics in human functional magnetic resonance imaging

Gauthier, C., Madjar, C., Desjardins-Crépeau, L., Bellec, P., Bherer, L., & Hoge, R. D. (2013). Age dependence of hemodynamic response characteristics in human functional magnetic resonance imaging. Neurobiology of Aging, 34(5), 1469-1485. doi:10.1016/j.neurobiolaging.2012.11.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-77DF-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8CB5-3
Genre: Journal Article

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2012 GauthierAge dependence of hemodynamic response.pdf (Publisher version), 2MB
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 Creators:
Gauthier, Claudine1, 2, Author              
Madjar, Cécile2, Author
Desjardins-Crépeau, Laurence2, 3, Author
Bellec, Pierre2, 4, Author
Bherer, Louis2, 3, Author
Hoge, Richard D. 1, 2, Author
Affiliations:
1Department of Physiology, Institute of Biomedical Engineering, University of Montréal, QC, Canada, ou_persistent22              
2Centre de recherche de l'Institut universitaire de gériatrie de Montréal, QC, Canada, ou_persistent22              
3Department of Psychology, Université du Québec à Montréal (UQÀM), QC, Canada, ou_persistent22              
4Department of Computer Science and Operations Research, University of Montréal, QC, Canada, ou_persistent22              

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Free keywords: Cognitive aging; Calibrated fMRI; Hypercapnia; Vascular reactivity; BOLD signal biases; Cerebral blood flow; Oxidative metabolism; Modified Stroop task
 Abstract: Functional magnetic resonance imaging (fMRI) studies of cognitive aging have generally compared the amplitude and extent of blood oxygen level-dependent (BOLD) signal increases evoked by a task in older and younger groups. BOLD is thus used as a direct index of neuronal activation and it is assumed that the relationship between neuronal activity and the hemodynamic response is unchanged across the lifespan. However, even in healthy aging, differences in vascular and metabolic function have been observed that could affect the coupling between neuronal activity and the BOLD signal. Here we use a calibrated fMRI method to explore vascular and metabolic changes that might bias such BOLD comparisons. Though BOLD signal changes evoked by a cognitive task were found to be similar between a group of younger and older adults (e.g., 0.50 ± 0.04% vs. 0.50 ± 0.05% in right frontal areas), comparison of BOLD and arterial spin labelling (ASL) responses elicited in the same set of structures by a controlled global hypercapnic manipulation revealed significant differences between the 2 groups. Older adults were found to have lower responses in BOLD and flow responses to hypercapnia (e.g., 1.48 ± 0.07% vs. 1.01 ± 0.06% over gray matter for BOLD and 24.92 ± 1.37% vs. 20.67 ± 2.58% for blood flow), and a generally lower maximal BOLD response M (5.76 ± 0.2% vs. 5.00 ± 0.3%). This suggests that a given BOLD response in the elderly might represent a larger change in neuronal activity than the same BOLD response in a younger cohort. The results of this study highlight the importance of ancillary measures such as ASL for the correct interpretation of BOLD responses when fMRI responses are compared across populations who might exhibit differences in vascular physiology.

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Language(s): eng - English
 Dates: 2012-10-012012-07-222012-11-022012-12-062013-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neurobiolaging.2012.11.002
PMID: 23218565
PMID: Epub 2012
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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 34 (5) Sequence Number: - Start / End Page: 1469 - 1485 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902