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  A generalized procedure for calibrated MRI incorporating hyperoxia and hypercapnia

Gauthier, C., & Hoge, R. D. (2013). A generalized procedure for calibrated MRI incorporating hyperoxia and hypercapnia. Human Brain Mapping, 34(5), 1053-1069. doi:10.1002/hbm.21495.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-77E4-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8CAB-F
Genre: Journal Article

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2012 GauthierA generalized procedure for calibrated.pdf (Publisher version), 3MB
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 Creators:
Gauthier, Claudine1, 2, Author              
Hoge, Richard D.1, 2, Author
Affiliations:
1Department of Physiology, Institute of Biomedical Engineering, University of Montréal, QC, Canada, ou_persistent22              
2Centre de recherche de l'Institut universitaire de gériatrie de Montréal, QC, Canada, ou_persistent22              

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Free keywords: Calibrated fMRI; Hyperoxia; Hypercapnia; Oxidative metabolism; Visual stimulation
 Abstract: Calibrated MRI techniques use the changes in cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) signal evoked by a respiratory manipulation to extrapolate the total BOLD signal attributable to deoxyhemoglobin at rest (M). This parameter can then be used to estimate changes in the cerebral metabolic rate of oxygen consumption (CMRO(2)) based on task-induced BOLD and CBF signals. Different approaches have been described previously, including addition of inspired CO(2) (hypercapnia) or supplemental O(2) (hyperoxia). We present here a generalized BOLD signal model that reduces under appropriate conditions to previous models derived for hypercapnia or hyperoxia alone, and is suitable for use during hybrid breathing manipulations including simultaneous hypercapnia and hyperoxia. This new approach yields robust and accurate M maps, in turn allowing more reliable estimation of CMRO(2) changes evoked during a visual task. The generalized model is valid for arbitrary flow changes during hyperoxia, thus benefiting from the larger total oxygenation changes produced by increased blood O(2) content from hyperoxia combined with increases in flow from hypercapnia. This in turn reduces the degree of extrapolation required to estimate M. The new procedure yielded M estimates that were generally higher (7.6 ± 2.6) than those obtained through hypercapnia (5.6 ± 1.8) or hyperoxia alone (4.5 ± 1.5) in visual areas. These M values and their spatial distribution represent a more accurate and robust depiction of the underlying distribution of tissue deoxyhemoglobin at rest, resulting in more accurate estimates of evoked CMRO(2) changes.

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Language(s): eng - English
 Dates: 2011-08-172011-05-142011-09-222012-01-162013-05-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.21495
PMID: 23015481
Other: Epub 2012
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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 34 (5) Sequence Number: - Start / End Page: 1053 - 1069 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686