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  BOLD-perfusion coupling during monocular and binocular stimulation

Gauthier, C., & Hoge, R. D. (2008). BOLD-perfusion coupling during monocular and binocular stimulation. International Journal of Biomedical Imaging, 2008: 628718. doi:10.1155/2008/628718.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-77F1-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-C796-8
Genre: Journal Article

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2008 GauthierBOLD-Perfusion Coupling during Monocular and.pdf (Publisher version), 823KB
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 Creators:
Gauthier, Claudine1, 2, Author              
Hoge, Richard D.1, 3, Author
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1Unit ́e de Neuroimagerie Fonctionnelle, Institut Universitairy of G ́eriatrie de Montreal, Montreal, QC, Canada H3W 1W5, ou_persistent22              
2Department of Physiology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada H3W 1W5, ou_persistent22              
3Institute of Biomedical Engineering, Faculty of Medicine, University of Montreal, Montreal, QC, Canada H3W 1W5, ou_persistent22              

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 Abstract: Previous studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead to disproportionately large blood oxygenation level-dependent (BOLD) signal increases for a given flow increase during monocular (relative to binocular) stimulation, due to contributions from columns which undergo large increases in perfusion with little or no change in oxidative metabolism. In the present study, we sought to test this hypoth- esis by measuring BOLD-perfusion coupling ratios in spatially averaged signals over V1 during monocular and binocular visual stimulation. It was found that, although withholding input to one eye resulted in statistically significant decreases in BOLD and perfusion signals in primary visual cortex, the ratio between BOLD and perfusion increases did not change significantly. These results do not support a gross mismatch between spatial patterns of flow and metabolism response during monocular stimulation.

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Language(s): eng - English
 Dates: 2008-01-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1155/2008/628718
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Title: International Journal of Biomedical Imaging
Source Genre: Journal
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Publ. Info: Hindawi Publishing Corporation
Pages: - Volume / Issue: 2008 Sequence Number: 628718 Start / End Page: - Identifier: ISSN: 1687-4188
CoNE: /journals/resource/1687-4188