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  Comparison of pulsed and pseudocontinuous arterial spin-labeling for measuring CO2-induced cerebrovascular reactivity

Tancredi, F. B., Gauthier, C., Madjar, C., Bolar, D. S., Fisher, J. A., Wang, D. J. J., et al. (2012). Comparison of pulsed and pseudocontinuous arterial spin-labeling for measuring CO2-induced cerebrovascular reactivity. Journal of Magnetic Resonance Imaging, 36(2), 312-321. doi:10.1002/jmri.23658.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-77F4-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C99D-A
Genre: Journal Article

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2012 TancrediComparison of pulsed and pseudocontinuous.pdf (Publisher version), 2MB
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 Creators:
Tancredi, Felipe B.1, 2, Author
Gauthier, Claudine1, 3, Author              
Madjar, Cécile2, Author
Bolar, Divya S.4, 5, 6, Author
Fisher, Joseph A.7, Author
Wang, Danny J. J.8, Author
Hoge, Richard D.1, 2, 3, Author
Affiliations:
1Department of Physiology, Institute of Biomedical Engineering, University of Montréal, QC, Canada, ou_persistent22              
2Unité de neuroimagerie fonctionnelle, Centre de recherche de l'Institut universitaire de gériatrie de Montréal, QC, Canada, ou_persistent22              
3Department of Physiology, Faculty of Medicine, University of Montréal, QC, Canada, ou_persistent22              
4Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
5Harvard-MIT Health Sciences and Technology, Cambridge, MA, USA, ou_persistent22              
6Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA, ou_persistent22              
7Department of Anesthesia, University of Toronto, ON, Canada, ou_persistent22              
8University of California, Los Angeles, CA, USA, ou_persistent22              

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Free keywords: ASL; hypercapnia; cerebrovascular reactivity
 Abstract: PURPOSE: To compare the performance of pulsed and pseudocontinuous arterial spin-labeling (PASL and pCASL) methods in measuring CO(2) -induced cerebrovascular reactivity (CVR). MATERIALS AND METHODS: Subjects were scanned using both ASL sequences during a controlled hypercapnia procedure and visual stimulation. CVR was computed as the percent CO(2) -induced increase in cerebral blood flow (Δ%CBF) per mmHg increase in end-tidal PCO(2) . Visually evoked responses were expressed as Δ%CBF. Resting CBF and temporal signal-to-noise ratio were also computed. Regionally averaged values for the different quantities were compared in gray matter (GM) and visual cortex (VC) using t-tests. RESULTS: Both PASL and pCASL yielded comparable respective values for resting CBF (56 ± 3 and 56 ± 4 mL/min/100g) and visually evoked responses (75 ± 5% and 81 ± 4%). Values of CVR determined using pCASL (GM 4.4 ± 0.2, VC 8 ± 1 Δ%CBF/mmHg), however, were significantly higher than those measured using PASL (GM 3.0 ± 0.6, VC 5 ± 1 Δ%CBF/mmHg) in both GM and VC. The percentage of GM voxels in which statistically significant hypercapnia responses were detected was also higher for pCASL (27 ± 5% vs. 16 ± 3% for PASL). CONCLUSION: pCASL may be less prone to underestimation of CO(2) -induced flow changes due to improved label timing control.

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Language(s): eng - English
 Dates: 2011-02-212012-03-072012-04-272012-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/jmri.23658
PMID: 22544711
Other: Epub 2012
 Degree: -

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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 36 (2) Sequence Number: - Start / End Page: 312 - 321 Identifier: ISSN: 1053-1807
CoNE: /journals/resource/954925594512