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  Regional impact of field strength on voxel-based morphometry results

Tardif, C., Collins, D. L., & Pike, G. B. (2010). Regional impact of field strength on voxel-based morphometry results. Human Brain Mapping, 31(7), 943-957. doi:10.1002/hbm.20908.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-799E-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-C7A8-F
Genre: Journal Article

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 Creators:
Tardif, Christine1, Author              
Collins, D. Louis1, Author
Pike, G. Bruce1, Author
Affiliations:
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada, ou_persistent22              

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Free keywords: Magnetic resonance imaging; Neuroimaging; Morphology; Voxel-based morphometry; Field strength comparison
 Abstract: The objective of this study was to characterize the sensitivity of voxel-based morphometry (VBM) results to choice field strength. We chose to investigate the two most widespread acquisition sequences for VBM, FLASH and MP-RAGE, at 1.5 and 3 T. We first evaluated image quality of the four acquisition protocols in terms of SNR and image uniformity. We then performed a VBM study on eight subjects scanned twice using the four protocols to evaluate differences in grey matter (GM) density and corresponding scan-rescan variability, and a power analysis for each protocol in the context a longitudinal and cross-sectional VBM study. As expected, the SNR increased significantly at 3 T for both FLASH and MP-RAGE. Image non-uniformity increased as well, in particular for MP-RAGE. The differences in CNR and contrast non-uniformity cause regional biases between protocols in the VBM results, in particular between sequences at 3 T. The power analysis results show an overall decrease in the number of subjects required in a longitudinal study to detect a difference in GM density at 3 T for MP-RAGE, but an increase for FLASH. The number of subjects required in a cross-sectional VBM study is higher at 3 T for both sequences. Our results show that each protocol has a distinct regional sensitivity pattern to morphometric change, which goes against the classical view of VBM as an unbiased whole brain analysis technique, complicates the combination of data within a VBM study and the direct comparison of VBM studies based on different protocols.

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Language(s): eng - English
 Dates: 2009-102010-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/hbm.20908
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 31 (7) Sequence Number: - Start / End Page: 943 - 957 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686