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  Herstellung moderner Grippeimpfstoffe : Zellkultur statt Hühnerei

Genzel, Y., Frensing, T., & Reichl, U. (2013). Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit, 47(1), 12-22. doi:10.1002/ciuz.201200606.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-87E2-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-A74C-1
Genre: Journal Article

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 Creators:
Genzel, Yvonne1, Author              
Frensing, Timo1, Author              
Reichl, Udo1, 2, Author              
Affiliations:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Otto-von-Guericke-Universität Magdeburg, ou_1738156              

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Free keywords: Impfstoffproduktion, Influenza Virus, tierische Zellkultur, adhärente Zellen, Suspensionszellen
 Abstract: Today, about 95 % of the available influenza vaccine doses are still produced in embryonated chicken eggs. However, since the 2009 H1N1 influenza pandemic many people have realized that in case of a real threat, it might be difficult to guarantee the timely supply of a sufficient amount of vaccines. Therefore, it is of utmost importance to improve existing processes and to develop alternative manufacturing methods. The cell culture-based processes discussed in this manuscript represent a promising option to establish scalable and robust production processes. Probably these processes have not been pushed up to their limits yet. Further optimization concerning the design of bioprocesses and the optimization of biological systems involved could contribute significantly to increase yields and product quality. Copyright © 1999–2012 John Wiley & Sons, Inc. All Rights Reserved. [accessed November 29th 2012]

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Language(s): deu - German
 Dates: 2013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 628149
Other: 2/13
DOI: 10.1002/ciuz.201200606
 Degree: -

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Title: Chemie in unserer Zeit
  Other : Chem. Unserer Zeit
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 47 (1) Sequence Number: - Start / End Page: 12 - 22 Identifier: ISSN: 0009-2851
CoNE: /journals/resource/954925389249