English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Comment on "Load-induced modulation of signal transduction networks" : Reconciling ultrasensitivity with bifunctionality?

Straube, R. (2012). Comment on "Load-induced modulation of signal transduction networks": Reconciling ultrasensitivity with bifunctionality? Science Signaling, 5(205), Ic1. doi:10.1126/scisignal.2002699.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-89DB-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F477-9
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Straube, Ronny1, Author              
Affiliations:
1Analysis and Redesign of Biological Networks, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738139              

Content

show
hide
Free keywords: -
 Abstract: Jiang et al. (Research Article, 11 October 2011, DOI: 10.1126/scisignal.2002152) used a combined experimental and computational modeling approach to study the dynamic response behavior of covalent modification cycles in the presence of downstream targets ("loads"). Despite remarkable agreement between experiments and model predictions, there exists an apparent discrepancy in their approach because the utilized theoretical model does not reflect the bifunctional nature of the enzyme system used in experiments. Furthermore, a simple extension of the model to the case of bifunctional enzymes yields predictions that are partially at variance with the experimental results. It seems that an appropriate mechanistic model would have to reconcile two apparent contradictory concepts: ultrasensitivity and bifunctionality. © 2012 American Association for the Advancement of Science. All Rights Reserved. [accessed 2013 July 2nd]

Details

show
hide
Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science Signaling
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 5 (205) Sequence Number: - Start / End Page: Ic1 Identifier: -