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  Theoretical study of using simulated moving bed chromatography to separate intermediately eluting target compounds

Nowak, J., Antos, D., & Seidel-Morgenstern, A. (2012). Theoretical study of using simulated moving bed chromatography to separate intermediately eluting target compounds. Journal of Chromatography A, 1253, 58-70. doi:10.1016/j.chroma.2012.06.096.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-8A22-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B383-8
Genre: Journal Article

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 Creators:
Nowak, J.1, Author              
Antos, D.2, Author              
Seidel-Morgenstern, A.1, 3, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Rzeszow Univ Technol, Rzeszow, Poland, persistent:22              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Simulated Moving Bed chromatography; Ternary mixtures; Center-cut separations; SMB cascades; Pseudo SMB processes
 Abstract: This study deals with the separation of ternary mixtures based on Simulated Moving Bed chromatography to isolate target components with intermediate adsorption strength. To overcome the limitations of conventional SMB systems, which are designed for binary separations and unable to perform center-cut separations, several modifications have been proposed. The purpose of this study was to provide a theoretical comparison of several of advanced SMB configurations capable to separate ternary mixtures. Emphasis is given to those techniques, which have already been used in practice, and to those having potential for future industrial application. SMB cascades connected in series via the extract or raffinate ports of the first unit are analyzed and compared are as well as an integrated 8-zone SMB unit with internal recycle. Additionally, the commercialized pseudo SMB process (JO process) was evaluated. The performance of these modified SMB systems was investigated based on the assumption of linear adsorption isotherms for all three components considering three separation problems characterized by different separation difficulty. Besides the influence of separation factors, the concentrations of the impurities in the feed mixture and the purity requirements for the target product were studied systematically. Copyright © 2012 Elsevier B.V. All rights reserved. [accessed August 17th 2012]

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 611392
DOI: 10.1016/j.chroma.2012.06.096
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1253 Sequence Number: - Start / End Page: 58 - 70 Identifier: ISSN: 0021-9673
CoNE: https://pure.mpg.de/cone/journals/resource/954925527837_1