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  High-density microcarrier cell cultures for influenza virus production

Bock, A., Schulze-Horsel, J., Schwarzer, J., Rapp, E., Genzel, Y., & Reichl, U. (2011). High-density microcarrier cell cultures for influenza virus production. Biotechnology Progress, 27(1), 241-250. doi:10.1002/btpr.539.

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 Urheber:
Bock, A.1, Autor           
Schulze-Horsel, J.1, Autor           
Schwarzer, J.1, Autor           
Rapp, E.1, Autor           
Genzel, Y.1, Autor           
Reichl, U.1, 2, Autor           
Affiliations:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Otto-von-Guericke-Universität Magdeburg, ou_1738156              

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 Zusammenfassung: Influenza virus A/PR/8/34 virus propagation in adherent Madin-Darby canine kidney cells in high-density microcarrier cultures is described. To improve virus yields perfusion and repeated fed-batch modes were applied using cell-specific feed rates. Cell densities up to 1.1 x 107 cells/mL were achieved. Cell-specific virus yields in high-density cultures were at similar level compared to standard, low-density cultivations. In the average 2400 and 3300 virions per cell were obtained for two variants of the virus strain A/PR/8/34, PR8-NIBSC and PR8-RKI, respectively. Maximum virus titer (HA-activity = 1778 HAU/100μL) for virus variant PR8-NIBSC was obtained for a cultivation infected before maximum cell concentration was reached. Copyright © 1999-2010 John Wiley & Sons, Inc. All Rights Reserved. [accessed December 3rd 2010]

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Sprache(n): eng - English
 Datum: 2011
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 519942
DOI: 10.1002/btpr.539
Anderer: 47/10
 Art des Abschluß: -

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Titel: Biotechnology Progress
  Andere : Biotechnol. Prog.
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: New York, NY : American Institute of Chemical Engineers
Seiten: - Band / Heft: 27 (1) Artikelnummer: - Start- / Endseite: 241 - 250 Identifikator: ISSN: 8756-7938
CoNE: https://pure.mpg.de/cone/journals/resource/954925627362