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  Optimizing the separation of gaseous enantiomers by simulated moving bed and pressure swing adsorption

Bentley, J., Huang, Q., Kawajiri, Y., Eic, M., & Seidel-Morgenstern, A. (2011). Optimizing the separation of gaseous enantiomers by simulated moving bed and pressure swing adsorption. Adsorption, 17(1), 159-170. doi:10.1007/s10450-010-9299-x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-8CDD-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-82F0-2
Genre: Journal Article

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 Creators:
Bentley, J.1, Author
Huang, Q.2, Author
Kawajiri, Y.1, Author              
Eic, M.2, Author
Seidel-Morgenstern, A.3, 4, Author              
Affiliations:
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA USA, ou_persistent22              
2University of New Brunswick.Department of Chemical Engineering, Frederickton, NB E3B 5A3, Canada, ou_persistent22              
3Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
4Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Optimization – SMB – PSA – Adsorption – Enantiomer separation – Enflurane
 Abstract: The resolution of racemic gas mixtures by simulated moving bed (SMB) and pressure swing adsorption (PSA) is investigated by dynamic simulation and optimization. Enantiomer separation of inhalation anesthetics is important because there is evidence that the purified enantiomers may have different pharmacological properties than the racemate. The model parameters reported in an experimental investigation performed elsewhere are used to study the feasibility of this separation using SMB and PSA configurations. Both processes were modeled in gPROMS® as systems of differential algebraic equations. Operating conditions are optimized such that the feed throughput and product recovery for each process were maximized subject to equal constraints on the pressures and superficial gas velocities. SMB was found to be capable of resolving racemic feed mixtures with purity and recovery exceeding 99%. On the other hand, PSA was also able to provide a single purified enantiomer with low recovery of about 30% which may limit its application to enantiomer separation. Nevertheless, PSA consumes less desorbent, and achieves higher throughput at the sacrifice of lower recovery. © Springer Science+Business Media, LLC 2010 [accessed February 8th 2011]

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 528694
DOI: 10.1007/s10450-010-9299-x
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Title: Adsorption
Source Genre: Journal
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Publ. Info: Boston : Kluwer Academic Publishers
Pages: - Volume / Issue: 17 (1) Sequence Number: - Start / End Page: 159 - 170 Identifier: ISSN: 0929-5607
CoNE: https://pure.mpg.de/cone/journals/resource/954927383303_1