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  Multi-stage crystallization for resolution of enantiomeric mixtures in a solid solution forming system

Balawejder, M., Galan, K., Elsner, M. P., Seidel-Morgenstern, A., Piatkowski, W., & Antos, D. (2011). Multi-stage crystallization for resolution of enantiomeric mixtures in a solid solution forming system. Chemical Engineering Science, 66(22), 5638-5647. doi:10.1016/j.ces.2011.07.051.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-8DC9-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-573F-5
Genre: Journal Article

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 Creators:
Balawejder, Maciej1, Author
Galan, Kamila2, Author              
Elsner, Martin Peter2, Author              
Seidel-Morgenstern, Andreas2, 3, Author              
Piatkowski, Wojciech4, Author
Antos, Dorota4, Author              
Affiliations:
1University of Rzeszów,,Rzeszów, Poland, ou_persistent22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
4Rzeszow Univ Technol, Rzeszow, Poland, ou_persistent22              

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Free keywords: Crystallisation; Citalopram; Downstream processing; Enantiomers; Phase equilibria; Separations
 Abstract: A systematic procedure for synthesizing the multistage crystallization process was developed for resolution of enantiomeric mixtures involving solid solutions in the crystalline phase. The model compound investigated was citalopram oxalate, which revealed a complete solid solution in the solid phase. The counter-current multi-stage batch crystallization was suggested to isolate the target enantiomer from enantiomerically enriched mixtures. The solid-liquid equilibria in the presence of a solvent and the distribution diagrams were quantified and used in designing the crystallization process and defining adequate processing conditions. Different flowsheet schemes were considered and compared with respect to the process performance. The design procedure was verified by the experimental separation of enantiomeric mixtures of citalopram. Copyright © 2011 Elsevier Ltd All rights reserved. [accessed August 31st 2011]

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 570980
DOI: 10.1016/j.ces.2011.07.051
 Degree: -

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Title: Chemical Engineering Science
  Other : Chem. Eng. Sci.
Source Genre: Journal
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Affiliations:
Publ. Info: Amsterdam : Pergamon
Pages: - Volume / Issue: 66 (22) Sequence Number: - Start / End Page: 5638 - 5647 Identifier: ISSN: 0009-2509
CoNE: https://pure.mpg.de/cone/journals/resource/954925389239