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  Analysis and Comparison of Commonly Used Acidic Resolving Agents in Diastereomeric Salt Resolution – Examples for DL-Serine

Sistla, V. S., von Langermann, J., Lorenz, H., & Seidel-Morgenstern, A. (2011). Analysis and Comparison of Commonly Used Acidic Resolving Agents in Diastereomeric Salt Resolution – Examples for DL-Serine. Crystal Growth & Design, 11(9), 3761-3768. doi:10.1021/cg2001128.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-8DCB-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B40A-3
Genre: Journal Article

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 Creators:
Sistla, V. S.1, Author              
von Langermann, J.1, Author              
Lorenz, H.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: Diastereomeric salt resolution is still the most relevant technique in chiral resolution processes, e.g. for pharmaceutical relevant substances. For this purpose the choice of a suitable corresponding resolving agent is very important in respect of optimal yield, chemical purity and diastereomeric excess. Thus the solid phase behavior of diastereomeric salts is a crucial parameter and should be investigated prior to any resolution experiment. Within this contribution 3 commonly used acid resolving agents, 2,3-dibenzoyl-L-tartaric acid, L-(+)-mandelic acid, and L-(+)-tartaric acid, are compared for the resolution of the model compound DL-serine. The behavior of each diastereomeric salt pair was analyzed experimentally and is discussed with the help of phase diagrams. Copyright © 2011 American Chemical Society [accessed July 27th 2011]

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 570468
Other: 35/11
DOI: 10.1021/cg2001128
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Title: Crystal Growth & Design
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 11 (9) Sequence Number: - Start / End Page: 3761 - 3768 Identifier: ISSN: 1528-7483
CoNE: /journals/resource/110978984570353