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  The Potential of Chiral Solvents in Enantioselective Crystallization

Tulashie, S. K. (2010). The Potential of Chiral Solvents in Enantioselective Crystallization. PhD Thesis, docupoint, Barleben.

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 Creators:
Tulashie, S. K.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: The objective of this thesis is to evaluate the potential of applying chiral solvents for crystallization-based resolution of racemates. In general, it can be expected that a chiral solvent can discriminate two enantiomers by creating some weak interactions between the solvent and the substrate molecules forming diastereomeric complexes with different physical properties. This may lead to either asymmetry in the solubility phase diagrams or selective kinetic effects which can be employed for resolution purposes. To evaluate the prospect of using chiral solvents for crystallization based enantioseparation and to evaluate the potential of this approach, systematic experimental work is required. The chosen model systems studied experimentally in this work are two pharmaceutically interesting substances (mandelic acid and N-methylephedrine) which belong to the compound and conglomerate forming systems, respectively. Three different types of chiral solvents were studied: a “classical” chiral solvents, a chiral ionic liquids and a tailor-made chiral solvents.

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Language(s): eng - English
 Dates: 2010-07-27
 Publication Status: Accepted / In Press
 Pages: 208
 Publishing info: Barleben : docupoint
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 536192
ISBN: 978-3-86912-034-8
 Degree: PhD

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