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  The binary phase diagram of propranolol hydrochloride and crystallization-based enantioseparation

Polenske, D., Lorenz, H., & Seidel-Morgenstern, A. (2010). The binary phase diagram of propranolol hydrochloride and crystallization-based enantioseparation. Journal of Pharmaceutical Sciences, 99(4), 1762-1773. doi:10.1002/jps.21943.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9034-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B4CF-9
Genre: Journal Article

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 Creators:
Polenske, D.1, Author              
Lorenz, H.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: conglomerate • racemic compound • binary phase diagram • solid solutions • polymorphism • thermal analysis • calorimetry (DSC) • X-ray powder diffraction • separation science • chiral resolution • crystallization • propranolol hydrochloride
 Abstract: Inconsistent results were reported for the solid-state nature of the racemic species of the pharmaceutical relevant compound propranolol hydrochloride. In this work the binary phase diagram of the propranolol hydrochloride enantiomers is studied. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and high performance liquid chromatography (HPLC) were used as analytical methods. The type of the racemic species, the presence and extent of partial solid solutions and the stability regions of polymorphic forms in the system were investigated. The identified binary phase diagram is sketched. Finally, the feasibility of crystallization-based resolution is discussed. Copyright © 2009 Wiley-Liss, Inc., A Wiley Company. [accessed November 25, 2009]

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Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 437031
DOI: 10.1002/jps.21943
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Title: Journal of Pharmaceutical Sciences
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 99 (4) Sequence Number: - Start / End Page: 1762 - 1773 Identifier: -