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  Cyclic auto-seeded polythermal preferential crystallization – Effect of impurity accumulation

Czapla, F., Polenske, D., Klukas, L., Lorenz, H., & Seidel-Morgenstern, A. (2010). Cyclic auto-seeded polythermal preferential crystallization – Effect of impurity accumulation. Chemical Engineering and Processing, 49(1), 22-28. doi:10.1016/j.cep.2009.10.016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9038-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B463-8
Genre: Journal Article

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 Creators:
Czapla, F.1, Author              
Polenske, D.1, Author              
Klukas, L.1, Author              
Lorenz, H.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Crystallization; Process analytical technology; Preferential crystallization; Impurities
 Abstract: Preferential crystallization is a crystallization process where two enantiomers are separated into the pure chiral species. Usually the process is operated in a cyclic mode crystallizing the two species in sequel batches with an intermediate addition of fresh racemate. In this cyclic scheme reproducibility is a key issue. The reproducibility of the preferential crystallization of dl-(±)-threonine out of water using an auto-seeding procedure is investigated in this work. As in many processes that are based on recycling, accumulation of impurities is an issue of importance. In this work 10 separation batches (five cycles) are performed and monitored using a combination of four analytical devices (Polarimeter, densitometer, FBRM, PVM). An impurity that accumulates over the number of batches is detected using chiral HPLC. The reproducibility of the individual batches also with respect to the accumulating impurity is discussed based on the monitored trajectories. Copyright © 2010 Elsevier B.V. All rights reserved [accessed February 22, 2010]

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Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 438951
DOI: 10.1016/j.cep.2009.10.016
 Degree: -

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Title: Chemical Engineering and Processing
  Other : Chem. Eng. Process.
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Elsevier
Pages: - Volume / Issue: 49 (1) Sequence Number: - Start / End Page: 22 - 28 Identifier: ISSN: 0255-2701
CoNE: https://pure.mpg.de/cone/journals/resource/110992357312542