English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Solid−Liquid Phase Equilibria of N-Methylephedrine Enantiomers in Two Chiral Solvents

Kaemmerer, H., Tulashie, S. K., Lorenz, H., & Seidel-Morgenstern, A. (2010). Solid−Liquid Phase Equilibria of N-Methylephedrine Enantiomers in Two Chiral Solvents. Journal of Chemical and Engineering Data, 55(3), 1131-1136. doi:10.1021/je900572c.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9048-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B479-7
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kaemmerer, H.1, Author              
Tulashie, S. K.1, Author              
Lorenz, H.2, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              

Content

show
hide
Free keywords: -
 Abstract: The ternary solubility phase diagrams of the N-methylephedrine species in two chiral solvents, (S)-ethyl lactate and (2R,3R)-diethyl tartrate, have been studied. Solubility measurements were performed for enantiomeric compositions and temperatures ranging from 1:1 mixtures to the pure enantiomer and from (273 to 313) K. Predicted ideal solubility curves of the N-methylephedrine species in both solvents revealed deviations from experimental data. The nonrandom two-liquid model was applied to quantify and parametrize these nonidealities and nonideal heterochiral interactions among the enantiomers by means of corresponding activity coefficients. The solvent−solute interactions were interpreted as nonchiral specific, since no asymmetry in the chiral systems were found. The selection of an appropriate solvent for a crystallization-based enantioseparation based on the shape of solubility isotherms is discussed. Copyright © 2009 American Chemical Society. [accessed November 26, 2009]

Details

show
hide
Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 432863
Other: 30/10
DOI: 10.1021/je900572c
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Chemical and Engineering Data
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington : American Chemical Society
Pages: - Volume / Issue: 55 (3) Sequence Number: - Start / End Page: 1131 - 1136 Identifier: ISSN: 0021-9568
CoNE: https://pure.mpg.de/cone/journals/resource/991042728182784