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  Theoretical study of preparative chromatography using closed-loop recycling with an initial gradient

Sreedhar, B., Damtew Hamza, A., & Seidel-Morgenstern, A. (2009). Theoretical study of preparative chromatography using closed-loop recycling with an initial gradient. Journal of Chromatography A, 1216(25), 4976-4988. doi:10.1016/j.chroma.2009.04.057.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9270-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-DB50-C
Genre: Journal Article

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 Creators:
Sreedhar, B.1, 2, Author              
Damtew Hamza, Andualem1, 3, Author              
Seidel-Morgenstern, A.1, 3, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2International Max Planck Research School (IMPRS), Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, DE, ou_1738143              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Preparative chromatography; Closed-loop recycling; Gradient elution; Closed-loop recycling with initial gradient; Parallel grid search; Optimization; Craig model
 Abstract: Complementing classical isocratic elution, several more sophisticated operating modes have been proposed and are applied in preparative chromatography in order to improve performance. One such approach is gradient elution, where the solvent strength is altered by varying the fraction of a modifier added to the mobile phase to enhance selectivity and to achieve faster elution. Another useful technique is closed-loop recycling, allowing better peak resolution and increased yields. This study focuses on a modified new scheme which incorporates the advantages of both gradient elution and closed-loop recycling for the separation of a ternary mixture where the intermediately eluting component is the target. A parametric study was carried out using typical adsorption isotherm parameters to elucidate the effects of varying loading factors and parameters specific to the two basic operational modes on production rates and yields. A comparison was also made between the proposed scheme and conventional techniques. It was found that the studied scheme could exploit increased column loadings and offers significantly higher production rates. Copyright © 2009 Elsevier B.V. All rights reserved. [accessed July 27, 2009]

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Language(s): eng - English
 Dates: 2009
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 433492
DOI: 10.1016/j.chroma.2009.04.057
Other: 15/09
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1216 (25) Sequence Number: - Start / End Page: 4976 - 4988 Identifier: ISSN: 0021-9673