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Abstract:
Simulated Moving Bed (SMB) chromatography is a well-established process for the separation of binary mixtures. Various modifications of SMB systems have been proposed (e.g. [1,2]) due to increasing interest in isolating a target component out of a multicomponent feed mixture and the inability of conventional 4-zone SMB system to produce a pure product stream if the desired component is neither the strongest nor the weakest adsorbable component.
In this work a separation of ternary mixtures based on advanced SMB technology and the assumption of linear adsorption isotherms is investigated. Various combinations of classical 4-zone SMB units are studied with respect to their potential to produce and purify the intermediate component. Two coupled 4-zone SMB units connected in series by extract or raffinate port operated in semi-continuous or continuous mode are analysed and subsequently compared to an integrated 8-zone SMB unit with internal recycle. Several separation systems characterized by different separation factors, (e.g. lower, higher or equal values of separation factors for both separations) are studied.
The results obtained will be presented and discussed.
[1] P.C. Wankat, Ind. Eng. Chem. Res. 40 (2001) 6185.
[2] R.-M. Nicoud, Simulated Moving Bed Chromatography for Biomolecules, Academic Press, San Diego, CA, 2000.