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  Potential of different techniques of preferential crystallization for enantioseparation of racemic compound forming systems

Polenske, D., Lorenz, H., & Seidel-Morgenstern, A. (2009). Potential of different techniques of preferential crystallization for enantioseparation of racemic compound forming systems. Chirality, 21(8), 728-737. doi:10.1002/chir.20672.

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Polenske, D.1, Author              
Lorenz, H.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: chiral resolution; resolution by entrainment; seeded isothermal preferential crystallization; auto-seeded polythermal preferential crystallization; online monitoring; crystallization trajectory; mandelic acid
 Abstract: Recently the feasibility of preferential crystallization for enantioseparation of racemic compound forming systems has been demonstrated (Lorenz et al., Application of preferential crystallization to resolve racemic compounds in a hybrid process. Chirality 2006;18:828-840; Polenske et al., Separation of the propranolol hydrochloride enantiomers by preferential crystallization: thermodynamic basis and experimental verification. Cryst Growth Des 2007;7:1628-1634). Here, the development and the potential of an efficient separation process operated via two different techniques of preferential crystallization are studied: (1) seeded isothermal preferential crystallization and (2) auto-seeded polythermal preferential crystallization. Both techniques were investigated in the batch and in the cyclic operation mode. On the example of mandelic acid as a typical racemic compound forming system, it is demonstrated that a cyclic auto-seeded polythermal process is feasible and significantly more efficient than the seeded isothermal one. Copyright © 2009 Wiley-Liss, Inc., A Wiley Company [accessed July 24, 2009]

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Language(s): eng - English
 Dates: 2009
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 379766
DOI: 10.1002/chir.20672
 Degree: -

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Title: Chirality
  Other : Chirality
Source Genre: Journal
 Creator(s):
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Publ. Info: New York : J. Wiley
Pages: - Volume / Issue: 21 (8) Sequence Number: - Start / End Page: 728 - 737 Identifier: ISSN: 0899-0042
CoNE: https://pure.mpg.de/cone/journals/resource/954925561581