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  Time and Length Scales of Eddy Dispersion in Chromatographic Beds

Khirevich, S., Höltzel, A., Seidel-Morgenstern, A., & Tallarek, U. (2009). Time and Length Scales of Eddy Dispersion in Chromatographic Beds. Analytical Chemistry, 81(16), 7057-7066. doi:10.1021/ac901187d.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-93A3-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B548-9
Genre: Journal Article

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Khirevich, S.1, Author
Höltzel, A.1, Author
Seidel-Morgenstern, A.2, 3, Author              
Tallarek, U.1, Author
Affiliations:
1Philipps-Universität Marburg, Department of Chemistry, Marburg, Germany, ou_persistent22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: Time and length scales as well as the magnitude of individual contributions to eddy dispersion in chromatographic beds are resolved. We address this issue by a high-resolution numerical analysis of flow and mass transport in computer-generated bulk (unconfined) packings of monosized, nonporous, incompressible, spherical particles and complementary confined cylindrical packings with a cylinder-to-particle diameter ratio of dc/dp = 20. The transient behavior of longitudinal and transverse dispersion is analyzed and correlated with the spatial scales of heterogeneity in the bulk and confined packings. Simulations were carried out until complete transcolumn equilibration in the confined packings was achieved to facilitate a quantitative study of the geometrical wall effect. Longitudinal plate height data calculated over a wide range of reduced velocities (0.1 ≤ ν ≤ 500) were fitted to the comprehensive Giddings equation. The determined transition velocities for individual contributions to eddy dispersion were found to be widely disparate. As a consequence, the total effect of eddy dispersion on the plate height curves can be approximated in the practical range of chromatographic operational velocities (5 ≤ ν ≤ 20) by a composite expression in which only the short-range interchannel contribution retains its coupling characteristics, while transchannel and transcolumn contributions appear as simple mass transfer velocity-proportional terms. Copyright © 2009 American Chemical Society. [accessed November 25, 2009]

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Language(s): eng - English
 Dates: 2009
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 437227
DOI: 10.1021/ac901187d
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Title: Analytical Chemistry
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Chemical Society
Pages: - Volume / Issue: 81 (16) Sequence Number: - Start / End Page: 7057 - 7066 Identifier: ISSN: 0003-2700
CoNE: https://pure.mpg.de/cone/journals/resource/111032812862552