English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Logical network of genotoxic stress-induced NF-kB signal transduction predicts putative target structures for therapeutic intervention strategies

Poltz, R., Franke, R., Schweitzer, K., Klamt, S., Gilles, E. D., & Naumann, M. (2009). Logical network of genotoxic stress-induced NF-kB signal transduction predicts putative target structures for therapeutic intervention strategies. Advances and Applications in Bioinformatics and Chemistry, 2, 125-138. doi:10.2147/AABC.S8211.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9415-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-8B51-9
Genre: Journal Article

Files

show Files
hide Files
:
443825_adv_appl_bio_chem.pdf (Publisher version), 3MB
Name:
443825_adv_appl_bio_chem.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2009 Poltz et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

Locators

show

Creators

show
hide
 Creators:
Poltz, R.1, Author
Franke, R.1, Author
Schweitzer, K.1, Author
Klamt, S.2, Author              
Gilles, E. D.3, Author              
Naumann, M.1, Author
Affiliations:
1Otto von Guericke UniversityInstitute of Experimental Internal MedicineMagdeburg, ou_persistent22              
2Analysis and Redesign of Biological Networks, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738139              
3Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              

Content

show
hide
Free keywords: -
 Abstract: Genotoxic stress is induced by a broad range of DNA-damaging agents and could lead to a variety of human diseases including cancer. DNA damage is also therapeutically induced for cancer treatment with the aim to eliminate tumor cells. However, the effectiveness of radio- and chemotherapy is strongly hampered by tumor cell resistance. A major reason for radio- and chemotherapeutic resistances is the simultaneous activation of cell survival pathways resulting in the activation of the transcription factor nuclear factor-kappa B (NF-κB). Here, we present a Boolean network model of the NF-κB signal transduction induced by genotoxic stress in epithelial cells. For the representation and analysis of the model, we used the formalism of logical interaction hypergraphs. Model reconstruction was based on a careful meta-analysis of published data. By calculating minimal intervention sets, we identified p53-induced protein with a death domain (PIDD), receptor-interacting protein 1 (RIP1), and protein inhibitor of activated STAT y (PIASy) as putative therapeutic targets to abrogate NF-κB activation resulting in apoptosis. Targeting these structures therapeutically may potentiate the effectiveness of radio- and chemotherapy. Thus, the presented model allows a better understanding of the signal transduction in tumor cells and provides candidates as new therapeutic target structures. © 2009 Poltz et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. [accessed February 5th, 2010]

Details

show
hide
Language(s): eng - English
 Dates: 2009
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 443825
DOI: 10.2147/AABC.S8211
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advances and Applications in Bioinformatics and Chemistry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 2 Sequence Number: - Start / End Page: 125 - 138 Identifier: -