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  Metabolism of avian designer cells during influenza and MVA production

Lohr, V., Rath, A., Genzel, Y., Jordan, I., Sandig, V., & Reichl, U. (2008). Metabolism of avian designer cells during influenza and MVA production. Poster presented at Vaccine Technology II, Albufeira, Portugal.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-95D3-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-2011-B
Genre: Poster

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 Creators:
Lohr, V.1, Author              
Rath, A.1, Author              
Genzel, Y.1, Author              
Jordan, I., Author
Sandig, V., Author
Reichl, U.1, 2, Author              
Affiliations:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Otto-von-Guericke-Universität Magdeburg, ou_1738156              

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Free keywords: designer cell; MVA; influenza
 Abstract: As alternatives to well-established cell lines such as Vero or BHK cultures new designer cells are under consideration for vaccine production. Potential candidates are ProBioGen’s avian cells (AGE1.CR and AGE1.CR.pIX)1. Both cell lines grow in suspension in serum free medium (SFM) and can be productively infected with different influenza strains2 and MVA3. To identify optimal cultivation conditions for vaccine production, the cell lines must be characterized first. Metabolic data together with cell density and virus titers were evaluated in this work for different process conditions involving media (SFM1, SFM2), cultivation vessels (T-flasks, roller bottles, wave bioreactor) and infection conditions. In the following, we present data for the cultivation and infection of both CR and CR.pIX cells with influenza and MVA.

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Language(s): eng - English
 Dates: 2008
 Publication Status: Not specified
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 367143
Other: LohrRathGenzelJordanSandigReichl2008
 Degree: -

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Title: Vaccine Technology II
Place of Event: Albufeira, Portugal
Start-/End Date: 2008-01-06 - 2008-06-06

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