English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Mathematical modeling and analysis of insulin clearance in vivo

Koschorreck, M., & Gilles, E. D. (2008). Mathematical modeling and analysis of insulin clearance in vivo. BMC Systems Biology, 2, 43. doi:10.1186/1752-0509-2-43.

Item is

Files

show Files
hide Files
:
eDoc_366452_2008.pdf (Publisher version), 412KB
Name:
eDoc_366452_2008.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2008 Koschorreck and Gilles; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Locators

show

Creators

show
hide
 Creators:
Koschorreck, M.1, Author           
Gilles, E. D.1, 2, Author           
Affiliations:
1Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
2Integrated Navigation Systems, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738142              

Content

show
hide
Free keywords: -
 Abstract: Background: Analyzing the dynamics of insulin concentration in the blood is necessary for a comprehensive understanding of the effects of insulin in vivo. Insulin removal from the blood has been addressed in many studies. The results are highly variable with respect to insulin clearance and the relative contributions of hepatic and renal insulin degradation. Results: We present a dynamic mathematical model of insulin concentration in the blood and of insulin receptor activation in hepatocytes. The model describes renal and hepatic insulin degradation, pancreatic insulin secretion and nonspecific insulin binding in the liver. Hepatic insulin receptor activation by insulin binding, receptor internalization and autophosphorylation is explicitly included in the model. We present a detailed mathematical analysis of insulin degradation and insulin clearance. Stationary model analysis shows that degradation rates, relative contributions of the different tissues to total insulin degradation and insulin clearance highly depend on the insulin concentration. Conclusions: This study provides a detailed dynamic model of insulin concentration in the blood and of insulin receptor activation in hepatocytes. Experimental data sets from literature are used for the model validation. We show that essential dynamic and stationary characteristics of insulin degradation are nonlinear and depend on the actual insulin concentration. © 2008 Koschorreck and Gilles; licensee BioMed Central Ltd. [accessed July 4, 2008]

Details

show
hide
Language(s): eng - English
 Dates: 2008
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 366452
Other: 11/08
DOI: 10.1186/1752-0509-2-43
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: BMC Systems Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 2 Sequence Number: - Start / End Page: 43 Identifier: -